P112 Effects of Probiotic in Prevention of Radiation-Induced Diarrhea

Castro, Mariana Guimaraes De Oliveira; Sanchez, P.X.; Glasberg, João; Horie, L.M.; Waitzberg, D.L.

doi:10.1016/s1744-1161(09)70162-0

Cited by 13 publications

(8 citation statements)

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“…The mean age of the participants ranged from below 18 years to 75 years [9,12,13,[21][22][23][24][25]. Five studies exclusively discuss gynecological cancers including uterine and cervical cancer [9,13,22,24,25] and the rest discuss n other abdominal pelvic tumors including sigmoid, colorectal, prostate and bladder cancer in addition to the gynecological cancers [12,21,23]. Patients in all the trials receive radiotherapy, and three of the trial participants also receive chemotherapy [9,22,25].…”

Section: Population Characteristicsmentioning

confidence: 99%

“…Out of the eight trials, four trials were of high risk [9,[21][22][23], and one trial was of low risk [21]. In total, three trials were of some concern or uncertain risk of bias [12,13,24].…”

Section: Quality Assessment (Rob)mentioning

confidence: 99%

“…Second, there are extensive differences in the study populations, including the location of study, and patient-related variables such as gender, weight, smoking status and co-morbidities, as well as the severity of the cancer and RID. For example, five studies [9,13,15,22,24] look at female patients only with gynecological cancers and three studies [12,21,23] look at abdominal cavity cancers in both genders. Another example is that Linn et al conducted their study in a developing Asian country as compared to Salminen et al, who conducted theirs in a fully developed European country [13,22], thereby there may be significant differences in the standard of facilities and access to treatment.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

See 2 more Smart Citations

The Effects of Probiotic Supplementation on the Incidence of Diarrhea in Cancer Patients Receiving Radiation Therapy: A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials

et al. 2019

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The protective effects of probiotic supplementation against radiation-induced diarrhea (RID) have been reported in previous systematic reviews; however so far, only non-conclusive results have been obtained. The objective of this study was to systematically update and evaluate the available evidence for probiotic supplementation. The protocol of this systematic review has been registered (CRD42018106059) with the International Prospective Register of Systematic Reviews (PROSPERO). The primary efficacy outcome was the incidence of RID. Secondary outcomes were the incidence of watery stool, soft stool, and antidiarrheal medication use. There were eight trials, and a total of 1116 participants were included in the primary analysis. Compared with placebo, probiotics were associated with a lower risk of RID [risk ratio (RR) = 0.62, 95% CI = 0.46, 0.83]. A requisite heterogeneity-adjusted trial sequential analysis indicated conclusive evidence for this beneficial effect. No statistically significant reduction in RID (RR = 0.52, 95% CI = 0.14, 1.91) was observed on subgroup analysis in patients receiving both radiation therapy and chemotherapy. However, those patients receiving only radiation therapy (RT) demonstrated significant benefit (RR = 0.61, 95% CI = 0.48, 0.78). There was a significant difference in the antidiarrheal medication use (RR = 0.54, 95% CI = 0.35, 0.84) observed with the use of probiotics. However, no significant difference was observed for the incidence of soft and watery stool. The use of probiotics is beneficial in preventing RID in patients receiving RT.

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Section: Population Characteristicsmentioning

confidence: 99%

Section: Quality Assessment (Rob)mentioning

confidence: 99%

Section: Strengths and Limitationsmentioning

confidence: 99%

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The Effects of Probiotic Supplementation on the Incidence of Diarrhea in Cancer Patients Receiving Radiation Therapy: A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials

et al. 2019

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“…High risk was mainly about blinding issues, which had not been stated in some studies, 5,9 and with one study published only as abstracts. 18 Unclear risks were revealed in quality assessment, because the handling of incomplete outcome data and performance of intention-to-treat analysis were always ambiguous.…”

Section: Included Studiesmentioning

confidence: 99%

“…12,13 Several clinical trials have shown the efficiency of probiotics in patients undergoing pelvic radiotherapy and chemotherapy. 5,9,[14][15][16][17][18][19][20][21] However, both their dosages, bacterial strains and time of therapy were short of homogeneity. In addition, some of studies have not shown a positive curative effect and improvement of the quality of patients.…”

Section: Introductionmentioning

confidence: 99%

The efficacy and safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in people with abdominal and pelvic cancer: a systematic review and meta-analysis

Wang

et al. 2016

Eur J Clin Nutr

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A systematic review and meta-analysis were designed to evaluate the efficacy and safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in people with abdominal and pelvic cancer. We searched the Cochrane Library, PubMed, EMBASE and Web of Science up to November 2015. We also hand searched the citation lists of included studies and previously identified systematic reviews to identify further relevant trials. Odds ratio (OR) was used to compare efficacy, and the pooled OR was estimated using a random effects model; heterogeneity was assessed with Cochran's Q and the Higgins' I-test. Two reviewers assessed trial quality and extracted data independently. Analysis and bias for each included study were performed using Review Manager 5.2. Nine randomized and placebo-controlled studies (N=1265 participants) were included for assessing efficacy, of which seven were about radiotherapy and two about chemotherapy. Probiotic groups were compared with control groups with respect to the the incidence of diarrhea, OR=0.47 (95% confidence interval 0.28-0.76; P=0.002). Eleven studies, including 1612 people (873 consuming probiotics and 739 not consuming probiotics), were used for the analysis of safety of probiotics. Of the 11 studies, seven studies had no adverse events (AEs) caused by probiotics, whereas four studies reported varying degrees of AEs in their treatment. Probiotics may have a beneficial effect in prevention of chemoradiotherapy-induced diarrhea generally, especially for Grade⩾2 diarrhea. Probiotics may rarely cause AEs.

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A systematic review and meta-analysis of probiotics for the management of radiation induced bowel disease

2013

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P112 Effects of Probiotic in Prevention of Radiation-Induced Diarrhea

Cited by 13 publications

References 0 publications

The Effects of Probiotic Supplementation on the Incidence of Diarrhea in Cancer Patients Receiving Radiation Therapy: A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials

The Effects of Probiotic Supplementation on the Incidence of Diarrhea in Cancer Patients Receiving Radiation Therapy: A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials

The efficacy and safety of probiotics for prevention of chemoradiotherapy-induced diarrhea in people with abdominal and pelvic cancer: a systematic review and meta-analysis

A systematic review and meta-analysis of probiotics for the management of radiation induced bowel disease

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