p11 is up-regulated in the forebrain of stressed rats by glucocorticoid acting via two specific glucocorticoid response elements in the p11 promoter

Zhang, L; Li, H; Su, Tung‐Ping; Barker, Jeffery L.; Maric, Dragan; Fullerton, Carol S.; Webster, Maree J.; Hough, Christopher J.; Li, X X; Ursano, Robert J.

doi:10.1016/j.neuroscience.2008.03.022

Cited by 61 publications

(47 citation statements)

References 31 publications

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“…In the nuclei, GR binds to the GRE in the p11 promoter and regulates p11 expression. This hypothesis was supported by our previous findings, which showed that either treatment with a GR antagonist or mutation of the GRE in the p11 promoter abolished glucocorticoidinduced p11 over-expression (Zhang et al, 2008). Thus, stressinduced p11 expression is mediated by GR and GRE in the p11 promoter, and this circuit may be involved in stress-related diseases such as PTSD and affective disorders.…”

Section: Discussionsupporting

confidence: 75%

“…A previous study on the stress-related regulation of p11 identified two specific glucocorticoid receptor response elements (GRE) in the p11 promoter region (Zhang et al, 2008). Stressinduced glucocorticoids activate glucocorticoid receptors (GR), which translocate from the cytosol to the nuclear membrane.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that p11, a calcium binding protein, is associated with both depression (Svenningsson et al, 2006) and PTSD (Zhang et al, 2008). In the brain of patients, p11 mRNA was down-regulated in depression but up-regulated in PTSD.…”

mentioning

confidence: 86%

“…An association between p11 and depression was found in a p11 knock-out study in mice and in a post-mortem study in depressed patients (Anisman et al, 2008;Svenningsson et al, 2006). Stress-induced changes in p11 expression most likely result from the activation of the hypothalamuspituitary-adrenal (HPA) axis (Anisman et al, 2008;Zhang et al, 2008), indicating that there may be relationships between peripheral p11 mRNA levels and CNS activity. Using PET, recent studies found that BD patients have abnormal neural activity in the limbic-thalamic-cortical circuit (Salvadore et al, 2008).…”

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confidence: 99%

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P11 expression and PET in bipolar disorders

Zhang

et al. 2011

Journal of Psychiatric Research

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a b s t r a c tBackground: Bipolar disorder (BD) is a common mental disorder, subdivided into BD-I and BD-II. Currently, few biomarkers differentiate BD-I from BD-II. However, it is suggested that peripheral blood mononuclear cell (PBMC) mRNA levels of p11 and positron emission tomography (PET) might be potential biomarkers for BD. Results: Comparing BD patients to HCs, normalized glucose metabolism (NGM) was higher in the hippocampus, parahippocampus, and amygdala, but lower in the anterior cingulate cortex (aCC), medial prefrontal cortex (mPFC), dorsolateral prefrontal cortex (dlPFC), insula and thalamus. Compared to BD-II, BD-I had hypometabolism of glucose in the aCC, bilateral middle and inferior gyrus, insula and striatum, and hypermetabolism of glucose in the left parahippocampus. PBMC p11 mRNA was over-expressed in both BD-I and BD-II, although there was no significant difference in its expression levels between BD-I and B-II patients. Further, there were significant positive correlations between PBMC p11 mRNA and NGM in the mPFC, aCC, left insula, bilateral orbitofrontal cortex (OFC), and left middle, inferior and superior temporal gyri. Also, PBMC p11 mRNA was positively correlated to the number of depressive episodes in BD patients, especially in BD-I patients. Discussion: This study demonstrates that PBMC p11 mRNA expression is associated with neural activation in the brain of BD patients and warrants a larger translational study to determine its clinical utility.Published by Elsevier Ltd.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 86%

mentioning

confidence: 99%

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P11 expression and PET in bipolar disorders

Zhang

et al. 2011

Journal of Psychiatric Research

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“…Subject: Pre-clinical and clinical studies have shown the important role of p11 in Post-Traumatic Stress Disorder (PTSD) (Zhang 2008, 2009. CSTS, News From the Center, 2008CSTS, 2008 Annual Report;Army Annual Report 2009 andPsychiatric News Oct 2, 2009).…”

Section: Introductionmentioning

confidence: 99%

P11, a Biomarker for Memory Retrieval: A Possible Role in Traumatic Stress

Zhang¹

2011

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTThis is our annual report for the project: P11, A Biomarker for Memory Retrieval: A Possible Role in Traumatic Stress. We carried out all of the experiments based on the proposed research design. Due to all experiment dependent on the p11 knockout mice and the postponed scheduled p11 knockout mice development, we have tested memory retrieval performance with wild type mice. Fortunately, the detailed plan of p11 knockout mice development, such genotyping and delivery schedule has been approved by both our institution and The Jackson Laboratory (JAX). Currently, the p11 knockout mice have been breeding now at (JAX). As we proposed, we will use the p11 knockout mice to conduct two critical experiments to determine the effects of footshock on water-maze spatial task performance and to examine the role of p11 in memory retrieval performance in these mice. Our data from wild type of mice is the same as pervious reported: (1) Footshock and corticosterone significantly decreased the time spent on target and produced no effect on time spent on opposite, indicating a significant impaired performance in the water-maze spatial task in stressed mice compared to control in p11 wild type. (2) Stress resulted in p11 protein up-regulation, which as determined by Western Blot in the hippocampus, cortex and amygdala of wild type mice. (3) Stress and corticosterone resulted in p11 mRNA up-regulation, which as determined by real-time PCR in the hippocampus, a brain region associated with memory function. The ongoing final experiment with p11 knockout mice will allow us to accomplish all of our proposed specific aims.

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Cell‐ and region‐specific expression of depression‐related protein p11 (S100a10) in the brain

Milosevic

Liebmann

Knudsen

et al. 2016

J of Comparative Neurology

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P11 (S100a10), a member of the S100 family of proteins, has widespread distribution in the vertebrate body, including in the brain, where it has a key role in membrane trafficking, vesicle secretion and endocytosis. Recently, our laboratory has shown that a constitutive knockout of p11 (p11 KO) in mice results in a depressive-like phenotype. Furthermore, p11 has been implicated in major depressive disorder (MDD) and in the actions of antidepressants. Since depression affects multiple brain regions, and the role of p11 has only been determined in a few of these areas, a detailed analysis of p11 expression in the brain is warranted. Here we demonstrate that although widespread in the brain, p11 expression is restricted to distinct regions, and specific neuronal and non-neuronal cell types. Furthermore, we provide comprehensive mapping of p11 expression using in situ hybridization, immunocytochemistry and whole-tissue volume imaging. Overall, expression spans multiple brain regions, structures and cell types, suggesting a complex role of p11 in depression.

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p11 is up-regulated in the forebrain of stressed rats by glucocorticoid acting via two specific glucocorticoid response elements in the p11 promoter

Cited by 61 publications

References 31 publications

P11 expression and PET in bipolar disorders

P11 expression and PET in bipolar disorders

P11, a Biomarker for Memory Retrieval: A Possible Role in Traumatic Stress

Cell‐ and region‐specific expression of depression‐related protein p11 (S100a10) in the brain

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