P102 The effects of 17-β estradiol, medroxyprogesterone acetate and parathyroid hormone on akaline phosphatase activity in the osteoblastic cell line ros 17/2.8-5

Cho, Seung-Hun; Kj, Kim; Lee, Anna; Moon, Henry H.; Hwang, YY

doi:10.1016/s0378-5122(97)81294-7

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“…따라서 골다공증의 예방과 치료를 위하여 골 형성을 촉진시키는 방법에 관한 연구가 활발하게 이루어지고 있다. 특히, 생약제에 대한 효능 및 효과를 근거로 하여 골조직 재생능력에 미치는 영향 등에 대한 접근이 다양하게 시도되고 있다 (Cho et al, 1996;Boonen et al, 1997;Kwak et al, 2006;Kwon et al, 2011).…”

Section: 등의 부작용 유발 투여시기 조절의 어려움과 유방암 자궁암 간질환 등을 가진 특정 환자에 대한 적용상의 unclassified

Effects of Oleanolic Acid and its Derivatives on the Differentiation of MC3T3-E1 Osteoblastic Cell

Kim¹,

Lee²,

Jung³

et al. 2011

Korean Journal of Medicinal Crop Science

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: Ursolic acid, triterpenoid compound has been shown to stimulate osteoblast differentiation and enhance bone formation. In the present study, we examined the effects of similar triterpenoid compounds, oleanolic acid (OA) and its derivatives, such as oleanolic acid acetate (OAA) and oleanolic acetate methyl ester (OAM) on the bone formation in MC3T3-E1 osteoblast cells. We determined cellular proliferation, alkaline phosphatase (ALP) activity, mineralization, and expression of osteoblast specific genes and mitogen activated protein kinase phosphorylation. Treatment of 0.1-10µM OA, OAA, and OAM increased cellular proliferation, but not significantly increased as compared with dimethyl sulfoxide (DMSO). OA, OAA, and OAM at 5uM concentration enhanced ALP expression, mineralization, and osteocalcin (OCN) mRNA level. In conclusion, OA and its derivatives stimulated the osteoblast differentiation by increasing ALP, mineralization, and OCN mRNA expression. However, there were no significantly difference on osteoblast differentiation among treatment of OA, OAA, and OAM.

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Section: 등의 부작용 유발 투여시기 조절의 어려움과 유방암 자궁암 간질환 등을 가진 특정 환자에 대한 적용상의 unclassified

Effects of Oleanolic Acid and its Derivatives on the Differentiation of MC3T3-E1 Osteoblastic Cell

Kim¹,

Lee²,

Jung³

et al. 2011

Korean Journal of Medicinal Crop Science

View full text Add to dashboard Cite

show abstract

P102 The effects of 17-β estradiol, medroxyprogesterone acetate and parathyroid hormone on akaline phosphatase activity in the osteoblastic cell line ros 17/2.8-5

Cited by 1 publication

References 0 publications

Effects of Oleanolic Acid and its Derivatives on the Differentiation of MC3T3-E1 Osteoblastic Cell

Effects of Oleanolic Acid and its Derivatives on the Differentiation of MC3T3-E1 Osteoblastic Cell

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