P1012 Baroreflex Sensitivity in Children With Functional Gastrointestinal Disorders, Insulin-Dependent Diabetes Mellitus and in Normal Controls

Pytrus, Tomasz; Iwańczak, Barbara; Iwańczak, F

doi:10.1097/00005176-200406001-01136

Cited by 3 publications

(6 citation statements)

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“…Findings confirm the prediction that patients with IBS in general have significantly lower resting baroreceptor sensitivity compared to healthy controls [18,20]. Higher scores of blood pressure 3 and negative affect were also attributed to IBS patients.…”

Section: Discussionsupporting

confidence: 84%

“…For example, baroreceptor sensitivity (BRS) values at rest were found to be reduced in patients with IBS compared to a control group [18,20,21]. BRS is an autonomic measure of integrative sympathetic and parasympathetic regulation of cardiovascular processes assessed by blood pressure (BP) level and heart rate variability (HRV), and its resting values were found to be associated with mood regulation in our previous studies in healthy subjects and patients with major depression [22,23].…”

Section: Introductionmentioning

confidence: 99%

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Baroreflex mechanisms in Irritable Bowel Syndrome: Part I. Traditional indices

Davydov

Naliboff

Shahabi

et al. 2016

Physiology & Behavior

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Objective This study was conducted to present evidence of differences in autonomic regulation of cardiovascular activity and its role in the severity of specific (disease-related) and non-specific (negative affect and chronic pain-related) symptoms in individuals with Irritable Bowel Syndrome (IBS). Methods Seventy-eight female patients with IBS and 27 healthy women age 18–62 years were assessed for IBS symptoms, negative affect, and baroreceptor sensitivity (BRS), blood pressure (BP), heart rate, and heart rate variability (HRV) at rest. Direct and indirect regression effects were examined with application of the bootstrap procedure to validate findings. Results IBS was reliably related to lower resting BRS, higher BP, and higher negative affect compared to healthy controls. Longer disease duration (chronicity) was related to BRS decrease coupled with systolic BP increase (95% CIs = -0.14 to -0.01). Three autonomic mechanisms associated with BRS decrease were found to further regulate severity of IBS symptoms. Lower BRS was related to higher IBS severity in general if the effect was transferred through the decrease of low frequency power of HRV (e.g., 95% CIs = -0.039 to -0.001 for abdominal pain severity). However, lower BRS was related to lower IBS severity in general if the effect was transferred through diastolic BP increase (95% CIs = 0.01 to 0.11 for abdominal pain severity). Lower BRS was related to higher abdominal pain severity coupled with high negative affect if the effect was transferred through the decrease of higher frequency power of HRV (95% CIs = -0.026 to -0.003). Conclusions These findings indicate that different cardiovascular mechanisms are associated with IBS development and the increase and decrease of severity of IBS symptoms. Their assessment suggests ways to personalize treatment of IBS.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Baroreflex mechanisms in Irritable Bowel Syndrome: Part I. Traditional indices

Davydov

Naliboff

Shahabi

et al. 2016

Physiology & Behavior

View full text Add to dashboard Cite

show abstract

“…Autonomic testing as a metric for pain remains ill defined despite parasympathetic drivers of nociception and sympathetic drivers related to the pain distress indicated by baroreflex mechanisms regulating blood pressure (BP) were first discovered 33 years ago . The main methodological caveat of this autonomic metric of pain is hypothesized to be related to the generalization of the findings in healthy populations regarding parasympathetic and sympathetic cardiovascular (CV) mechanisms as symmetrical in reciprocal power for baroreflex regulation of BP to patients with chronic pain …”

Section: Introductionmentioning

confidence: 99%

“…Baroreflex activity was found to be affected by afferent stimulation, and that may play an important role in the pathophysiology of both chronic pain and comorbid (somatic and mental) disorders . For example, BRS is reduced in patients with IBS irrespective of its specific subpopulations compared to healthy subjects, and this reduction increases with IBS duration and severity . However, the similarly reduced BRS in IBS patients was found to be related to opposite pain killing and pain aggravating (related either to affect or sensation) mechanisms depending on mediation of this BRS reduction through BP or heart rate (HR) regulation processes .…”

Section: Introductionmentioning

confidence: 99%

“…3 The main methodological caveat of this autonomic metric of pain is hypothesized to be related to the generalization of the findings in healthy populations regarding parasympathetic and sympathetic cardiovascular (CV) mechanisms as symmetrical in reciprocal power for baroreflex regulation of BP [4][5][6] to patients with chronic pain. [7][8][9][10][11] Activity of the autonomic nervous system is altered in chronic pain disorders in general including chronic visceral pain disorders such as irritable bowel syndrome (IBS). 9,10,[12][13][14][15][16][17][18] In most previous studies, these alterations have been investigated using traditional indicators of CV system regulation such as baroreflex sensitivity (BRS), heart rate variability (HRV), and BP.…”

mentioning

confidence: 99%

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