P10 MIR-133a overexpression impairs endothelial cell migration and tube formation in vitro

Kurusamy, Sathishkumar; Ihugba, Jude C; Armesilla, Ángel Luis; Cotton, James

doi:10.1136/heartjnl-2018-bscr.15

Cited by 1 publication

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“…For example, overexpression of miR-133a significantly reduced cardiac fibrosis and disrupted the phosphorylation of ERK1/2 and SMAD-2 [152]. miR-133a also has an anti-angiogenic effect, as expression of this miRNA reduced VEGF-induced proliferation of endothelial cells in HUVEC by also targeting ERK1/2 phosphorylation [153]. In addition, miR-103-3p was found to play an important role in preventing apoptosis and autophagy of cardiomyocytes under hypoxia/reoxygenation, as inhibition of miR-103a-3p leads to Atg5 being able to promote apoptosis and autophagy in cells [118].…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

Potential Roles of microRNAs for Assessing Cardiovascular Risk in Pre-Eclampsia-Exposed Postpartum Women and Offspring

Mohd Isa,

Syafruddin,

Mokhtar

et al. 2023

IJMS

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Pre-eclampsia, which is part of the spectrum of hypertensive pregnancy disorders, poses a significant health burden, contributing to maternal and infant morbidity and mortality. Pre-eclampsia is widely associated with persistent adverse effects on the cardiovascular health of women with a history of pre-eclampsia. Additionally, there is increasing evidence demonstrating that offspring of pre-eclamptic pregnancies have altered cardiac structure and function, as well as different vascular physiology due to the decrease in endothelial function. Therefore, early detection of the likelihood of developing pre-eclampsia-associated cardiovascular diseases is vital, as this could facilitate the undertaking of the necessary clinical measures to avoid disease progression. The utilisation of microRNAs as biomarkers is currently on the rise as microRNAs have been found to play important roles in regulating various physiological and pathophysiological processes. In regard to pre-eclampsia, recent studies have shown that the expression of microRNAs is altered in postpartum women and their offspring who have been exposed to pre-eclampsia, and that these alterations may persist for several years. This review, therefore, addresses changes in microRNA expression found in postpartum women and offspring exposed to pre-eclampsia, their involvement in cardiovascular disease, and the potential role of microRNAs to be used as predictive tools and therapeutic targets in future cardiovascular disease research.

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Section: Limitations and Future Directionsmentioning

confidence: 99%