P1 Antiproliferative and apoptosis induction of methanolic extract from Muntingia calabura L leaves on WiDr colorectal cancer cell line

Desrini, Sufi; Purnamasari, Destika

doi:10.1016/j.bcp.2017.06.002

Cited by 2 publications

(1 citation statement)

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“…Indonesia has diverse potential natural medicine sources, one of them is M. Calabura which has the immense pharmacological ability, including anti-nociceptive [20], anti-proliferative [21], antimicrobial, cytotoxicity [22], anti-oxidant, anti-inflammatory both fruit [24], also stem bark parts [25] and hepatoprotective [26] from the leaves. Flavonoid is M. Calabura's primary bioactive compound responsible for pharmacological effects in M. Calabura [27].…”

Section: Introductionmentioning

confidence: 99%

Prediction of Active Compounds of Muntingia Calabura as Potential Treat-Ment for Chronic Obstructive Pulmonary Diseases by Network Pharmacology Integrated With Molecular Docking

NURHASANAH

Fadilah²

2023

Int J App Pharm

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Objective: Electronic cigarettes (E-Cigarettes) are often advertised as a safe alternative to smoke cessation. The number of E-Cigarettes users (vapers) has increased in many countries. The health impact of E-Cigarettes research topics still counting constitutes initiating Chronic Obstructive Pulmonary Disease (COPD). This research aimed to analyze the interaction between genes from E-Cigarettes causing COPD with Muntingia Calabura leaves, which has umpteen pharmacological effects through Bioinformatics. Methods: The related genes in E-Cigarettes compounds underlying COPD conditions were screened and intersected towards M. Calabura's genes target. The constructed networks were analyzed for their protein-protein interaction and pathway possibilities. The gene with the best betweenness centrality, closeness centrality, and degree value was validated using molecular docking methods for its interaction with M. Calabura leaves. Results: 12 target genes of M. Calabura and COPD were ALB, MMP-9, ICAM-1, GADPH, VEGFA, MPO, AKT1, ELANE, CXCR2, CFRTR, HSPA1A, and ADRB2. MMP-9 had the best value and then became the gene docked with M. Calabura compounds. The signaling propensity probably was PI3K/AKT pathway. M. Calabura has potentiated as a neutrophil inhibitor to balance protease/anti-protease. From molecular docking analyses, we found that 5,7-Dihydroxy-6-methoxyflavone gave the best conformation with MMP-9 with a binding affinity value of-10 kcal/mol. Conclusion: M. Calabura can be considered a natural source of candidates for COPD treatment.

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