Abstract:1). All hemispheres were imaged ex vivo on a 3T MRI scanner. An experienced observer manually outlined WMH on ex-vivo MRI. The white matter of each hemisphere was segmented into periventricular and deep white matter, and each segment was further divided into frontal, temporal, and parieto-occipital regions, using an automated approach. The total volume of WMH in each of the six white matter segments was measured for each hemisphere. Regional WMH burden was then defined as the square root of the regional WMH vo… Show more
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