P1-247 Cerebrovascular disease in 48 countries: secular trends in mortality 1950-2005

Abstract

Nottingham, Gwynedd and Neath Port Talbot). Eligible individuals were randomly selected from primary care trusts to health board registries. Assessment consists on multi-dimensional aspects of health, collection of saliva samples, and permission for review of general practice medical records. Those, who consent, will be flagged with the National Health Service central register to provide details of the date and cause of death. Results Collection of data are still ongoing and we will present what was collected up until December 2011. Conclusions CFAS II, in combination with its parent study will address key questions about health, diseases, associated disability, policy projections across generations of older people, who will reach the age of greatest frailty in the 2020s when the peak in numbers of 85 and over is expected. Background As the world population is ageing, and ageing is often stereotyped as a time of mental restriction and inflexibility, individuals make flexible use of available resources, including recruiting regions and other cognitive processes. Our aim is to identify what determines successful ageing across the adult lifespan into old age of cognitive abilities such as memory, attention, emotion, language and action. Methods A population-based cohort of 3000 adults, aged 18+, will be recruited with demographic and basic cognitive assessments. Of these, 700, aged 18e87 with 100 per decile, will be selected for comprising structural and functional neuroimaging [MRI and magnetoencephalography (MEG)] and neuropsychological tests. We will measure neural integrity and integration across cortical regions. On a subset of 280 adults further investigations will use functional MRI, MEG and electroencephalogram, and further behavioural testing. Formal statistical models will be used to examine the changes that occur with healthy ageing, and the reorganisation in terms of strategies and structures invoked to compensate for them. This approach offers hypothesis-driven insights into healthy ageing that are relevant to the general population. Results Collection of data started in Jan-11, with the initial cohort taking 2 years to recruit and a further 3 years for all detailed investigations. Conclusions Our research will generate a unique resource of neuroimaging and cognitive measures about change across the adult lifespan. Our analysis will help us to identify what characterises older adults with preserved performance and how normal ageing differs from pathological ageing in conditions such as Alzheimer's disease. P1-245 CAMBRIDGE CENTRE FOR AGEING AND NEUROSCIENCE (CAMCAN) STUDY PROTOCOL