P1–143: Olfactory stress test (OST) performance in cognitively normal elders is associated with apolipoprotein E (APOE) genotype

Schofield, Peter R.; Moore, Tammie; Finnie, Sally; Ebrahimi, Houman

doi:10.1016/j.jalz.2013.05.365

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AE but not baseline UPSIT differed between controls and those with cognitive impairment. In a separate study of cognitively normal elders, AE but not baseline UPSIT was associated with APOE genotype [64]. In an unpublished study, mean AE differed between normal controls and individuals with mild AD (CDR 0.5-1) but not those with PD.…”

Section: Primary Care Screening For Early Ad and Olfactory Testingmentioning

confidence: 84%

The Role of Olfactory Challenge Tests in Incipient Dementia and Clinical Trial Design

Schofield

Finnie

Yong

2014

Curr Neurol Neurosci Rep

Self Cite

View full text Add to dashboard Cite

The brain changes associated with Alzheimer's disease (AD) develop slowly over many years before the onset of dementia. Biomarkers for AD that allow its detection during this clinically silent phase will be hugely important when disease-modifying treatments that halt or slow its progression become available. Early detection, leading to early treatment, may in some cases avert dementia. Biomarkers aid our understanding of the presymptomatic stages of the disease and enable the identification of individuals with early disease who, by participating in clinical trials of investigational treatments with disease-modifying potential, contribute unique and vital information necessary to evaluate novel therapies. Most currently available AD biomarkers are expensive and not widely available and there are major efforts underway to find cheaper, simpler options. The olfactory system is affected by AD and the results from simple and inexpensive tests of the sense of smell, especially when paired with other information, can help identify individuals early in the disease. We review recent literature relevant to the use of simple olfactory tests, including some novel approaches, as aids to the early detection of AD. We consider their possible role in the design and conduct of clinical trials and suggest how in the future, when more effective treatments become available, they might be integrated into screening programs for early AD detection.

show abstract

Section: Primary Care Screening For Early Ad and Olfactory Testingmentioning

confidence: 84%

The Role of Olfactory Challenge Tests in Incipient Dementia and Clinical Trial Design

Schofield

Finnie

Yong

2014

Curr Neurol Neurosci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

P1–143: Olfactory stress test (OST) performance in cognitively normal elders is associated with apolipoprotein E (APOE) genotype

Cited by 1 publication

References 0 publications

The Role of Olfactory Challenge Tests in Incipient Dementia and Clinical Trial Design

The Role of Olfactory Challenge Tests in Incipient Dementia and Clinical Trial Design

Contact Info

Product

Resources

About