P1.01-004 Is There Any Role of Residential Radon in Non-Small Cell Lung Cancer (NSCLC) Patients Harboring Molecular Alterations?

Mezquita, Laura; Benito, Amparo; Olmedo, María Eugenia; Reguera, Pablo; Madariaga, Ainhoa; Villamayor, María; Cortez, Silvia Patricia; Gorospe, Luis; Santón, Almudena; Mayoralas, Sagrario; Hernánz, R.; Cabañero, Alberto; Carrato, Alfredo; Garrido, Pilar

doi:10.1016/j.jtho.2016.11.528

Cited by 2 publications

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“…The possible effect of residential radon on mutations/translocations in the driver genes EGFR and ALK is intriguing and provides a plausible new explanation for the different biological characteristics of lung cancer in never-smokers compared to ever-smokers. The only available studies were published by TAGA et al [17] and MEZQUITA et al [27] in 2012 and 2015, respectively. TAGA et al [17] observed no association between residential radon and EGFR mutations.…”

Section: Discussionmentioning

confidence: 99%

“…This high radon exposure provides a plausible explanation for its influence on the alterations of driver genes since high radon exposure is the most evident difference between the study by TAGA et al [17] and the present one. The study by MEZQUITA et al [27] included only 31 patients from Madrid (Spain), generally a low radon area. They observed that ALK rearrangements were associated with levels higher than the action levels recommended by WHO.…”

Section: Discussionmentioning

confidence: 99%

“…The lack of association between exposure to ETS and alterations in driver genes leaves the door open for a possible effect of alpha radiation on these genes. There is evidence for different molecular pathways for lung cancer in never-compared to ever-smokers, even in tumours of the same histological type, such as adenocarcinoma [27,29]. While it is not possible to completely explain the differences in residential radon level of patients whose tumours had an EGFR exon 19 deletion compared with those whose tumours had an exon 21 (L858R) singlepoint substitution mutation, alpha radiation likely induces cluster damage, leading to deletion events [30].…”

Section: Discussionmentioning

confidence: 99%

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Residential radon, EGFR mutations and ALK alterations in never-smoking lung cancer cases

et al. 2016

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The aim of this study was to assess if residential radon exposure might cause EGFR mutations or ALK rearrangements in never-smokers.We designed a multicentre case-control study in a radon-prone area (Galicia, Spain); only lung cancer cases were included in the study. We obtained residential radon measurements and clinical information for all the participants. We compared the median values of residential radon between patients with EGFR mutations or ALK rearrangements versus those without them.323 patients were included. Median age was 70 years and 19.5% were males. 42 and 15% of patients were EGFR- and ALK-positive, respectively. The most frequent EGFR alterations were exon 19 deletions and exon 21 (L858R) single-point substitution mutations. ALK-positive patients were 10 years younger than ALK-negative patients. Residential radon levels were two-fold higher in patients with exon 19 deletions compared with patients with exon 21 (L858R) single-point substitution mutations (216 versus 118 Bq·m; p=0.057). There were no differences in residential radon levels by EGFR mutation status. ALK-positive patients (n=12) essentially had two-fold residential radon levels compared with ALK-negative patients (290 versus 164 Bq·m, respectively).Residential radon may have a role in the molecular signature of lung cancer in never-smokers, although more studies with larger sample sizes are needed to support this hypothesis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Residential radon, EGFR mutations and ALK alterations in never-smoking lung cancer cases

et al. 2016

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“…These studies evaluated relationship between residual radon concentrations and driver gene status. Taga, Mezquita, Ruano-Ravina studied factors including radon focusing on the EGFR gene, ALK rearrangements, and both the EGFR gene and ALK rearrangements, respectively (24)(25)(26). These studies showed a statistical relationship between residual radon concentrations and the prevalence of driver gene mutations.…”

Section: Discussionmentioning

confidence: 99%

Elemental and mutational analysis of lung tissue in lung adenocarcinoma patients

Chiba

Morikawa

Sera

et al. 2019

Transl. Lung Cancer Res.

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Background: This study aimed to observe the association between trace element concentrations in lung tissue from lung adenocarcinoma cancer (LADC) patients and mutations in the epidermal growth factor receptor (EGFR) and KRAS genes.Methods: LADC patients who had undergone lung resection were included in this study. Furthermore, twenty patients without lung cancer were included in this study as the control group. Samples were separately collected from both tumor and peritumor tissues. The mutational status was assessed for EGFR mutations, ALK rearrangements and KRAS mutations. Based on these analyses, patients were grouped into three groups: EGFR mutation, KRAS mutation and wild-type groups. The concentrations of various trace elements in the lung tissues were measured by a particle-induced X-ray emission (PIXE) system, and the results were analyzed for statistical significance.Results: A total of 110 LADC patients were included in this study. The median age was 70 years, and 60% of the participants were female. Moreover, 18% and 20% of patients were EGFR-and KRASpositive, respectively. Thirty-two trace elements were measured, and 18 trace elements were detectable. The concentrations of Fe, Co, Ni, Cu, Zn and Br were significantly higher in the KRAS mutation and wild-type groups than in the control group regardless of whether the samples were from tumor or peritumor tissues.For these 6 trace elements, the concentrations were significantly higher in smokers than in non-smokers.Considering the effect of smoking, differences in the trace element concentrations between each mutational group remained. Conclusions:Trace elements in the lung may play a role in development of LADC in both smokers and never-smokers. However, prospective studies with larger sample sizes are needed to support this hypothesis.

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P1.01-004 Is There Any Role of Residential Radon in Non-Small Cell Lung Cancer (NSCLC) Patients Harboring Molecular Alterations?

Cited by 2 publications

References 0 publications

Residential radon, EGFR mutations and ALK alterations in never-smoking lung cancer cases

Residential radon, EGFR mutations and ALK alterations in never-smoking lung cancer cases

Elemental and mutational analysis of lung tissue in lung adenocarcinoma patients

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