P0899 Effects of Infant Formulas Containing Prebiotics or Probiotics on the Intestinal Flora During the First 4 Months of Life

Bakker-Zierikzee, AM; Alles, M.S.; Knol, Jan; Kok, F.J.; Tolboom, J.J.M.; Bindels, Jacques

doi:10.1097/00005176-200406001-01023

Cited by 3 publications

(2 citation statements)

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“…The characteristics of the study subjects are shown in Table 2. Results on the composition and metabolic activity of the intestinal microflora are published elsewhere (20). Of the 63 infants fed on breast milk directly after birth, 40 switched to complete or partial formula feeding, 12 were completely breastfed and 11 dropped out during the intervention period.…”

Section: Resultsmentioning

confidence: 99%

Faecal SIgA secretion in infants fed on pre‐ or probiotic infant formula

Bakker-Zierikzee

Tol²,

Kroes³

et al. 2006

Pediatric Allergy Immunology

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167

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Secretory immunoglobulin A (SIgA) plays an important role in the defence of the gastrointestinal tract. The level of faecal SIgA antibody is associated with increased neutralization and clearance of viruses. Formula-fed infants who lack the transfer of protective maternal SIgA from breast milk may benefit from strategies to support maturation of humoral immunity and endogenous production of SIgA. We aimed at studying the effects of standard, prebiotic and probiotic infant formulas on the faecal SIgA levels. At birth, infants of whom the mother had decided not to breastfeed were allocated to one of three formula groups in a randomized, double-blind fashion. Nineteen infants received standard infant formula; 19 received prebiotic formula containing a specific mixture of 0.6 g galacto-oligosaccharides (GOS)/fructo-oligosaccharides (FOS)/100 ml formula and 19 received probiotic formula containing 6.0 x 10(9) cfu Bifidobacterium animalis/100 ml formula. Faecal samples were taken on postnatal day 5, day 10, wk 4 and every 4 wk thereafter until wk 32. SIgA in faeces was determined by an enzyme-linked immunosorbent assay. During the intervention, infants fed on prebiotic formula showed a trend towards higher faecal SIgA levels compared with the standard formula-fed infants reaching statistical significance at the age of 16 wk. In contrast, infants fed on the probiotic formula showed a highly variable faecal SIgA concentration with no statistically significant differences compared with the standard formula group. Formula-fed infants may benefit from infant formulas containing a prebiotic mixture of GOS and FOS because of the observed clear tendency to increase faecal SIgA secretion. Adding viable B. animalis strain Bb-12 to infant formula did not reveal any sign for such a trend.

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Section: Resultsmentioning

confidence: 99%

Faecal SIgA secretion in infants fed on pre‐ or probiotic infant formula

Bakker-Zierikzee

Tol²,

Kroes³

et al. 2006

Pediatric Allergy Immunology

Self Cite

167

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“…There are mixed findings regarding the effectiveness of probiotic formulations over standard, term infant formulas in improving immune function and digestive symptoms; however, the most recent data show more positive findings. [36][37][38][39][40][41][42][43] Long-term effects of the use of probiotic formulations during infancy remain equivocal. 44 The use of oligosaccharides as prebiotics in infant formula may have positive effects on gut health through the promotion of selective strains of bacteria, which may in turn improve immune response.…”

Section: Discussionmentioning

confidence: 99%

Health Statements Made in Infant Formula Advertisements in Pregnancy and Early Parenting Magazines

Stang

Hoss

Story

2010

ICAN: Infant, Child, & Adolescent Nutrition

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Pregnant women and mothers of infants are the target audience for advertisements of infant formula. The purpose of this pilot study was to assess the prevalence and content of health statements made in infant formula advertisements found in pregnancy and early parenting magazines from August 2006 to August 2007. A total of 173 infant formula advertisements were found in 77 individual issues of 16 different magazines. Forty-two unduplicated advertisements were used for the content analysis. Statistical analysis included kappa scores, frequencies, and percentages. Results showed that 9 of the 16 magazines analyzed contained ads for infant formulas. Of these, more than half of all infant formula advertisements made some type of health statement. Health statements varied greatly but generally advertised improvements in gastrointestinal, brain, or eye health; language development; or reduced incidence of allergies, food intolerances, and gastrointestinal disorders. Such health statements may influence a mother’s decision on which method of infant feeding to provide. A greater understanding of how these statements are perceived by new mothers as well as how they affect infant feeding decisions is needed.

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