P066 Results of surgical treatment of localized and locally-advanced prostate cancer patients in subject to volume of lymph node dissection performed

Nyushko, K. M.; Алексеев, Б. Я.; Krasheninnikov, A.; Kalpinskiy, A. S.; Франк, Г. А.; Andreeva, Yu Yu; Каприн, А. Д.

doi:10.1016/s1569-9056(13)62391-x

Cited by 2 publications

(3 citation statements)

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“…Similarly, ePLND did not alter BCR rates at a median follow-up of 36 months in a retrospective study by Kim et al [40]. Furthermore, ePLND did not provide better biochemical outcome in four comparative studies [39,41,42]. However, all these studies were retrospective in design, and three of them were conference abstracts.…”

Section: Biochemical Recurrencementioning

confidence: 93%

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The Benefits and Harms of Different Extents of Lymph Node Dissection During Radical Prostatectomy for Prostate Cancer: A Systematic Review

et al. 2017

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The use of online course material is the approach adopted by most universities to support students' revision, and teachers usually have the responsibility for designing or uploading online materials on their own course websites. However, some teachers might lack programming skills or motivation, and most current online materials are just uploaded in a static format (such as PDF) which is not suitable for all students. Moreover, during revision periods students may be faced with a lot of unorganised materials to be revised in a short period of time, and this can lead to an ineffective revision process. In order to address these issues, this paper proposes a software framework that aims to maximise the benefit of current online materials when used to support student revision. This framework is called SRECMATs (Self-Revision E-Course MATerials) and has been deployed as a tool that allows teachers to automatically create an intelligent tutoring system to manage online materials without any programming knowledge, and to support students to navigate easily through these online materials during their revision. This paper evaluates the proposed framework in order to understand students' perceptions with regard to the use of the system prototype, and the results indicate which features are suitable for providing online revision materials as well as confirming the benefit of the revision framework.

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Section: Biochemical Recurrencementioning

confidence: 93%

“…Cancer-specific mortality was reported in one conference abstract [41] that showed that ePLND did not provide a statistically significant survival benefit over sPLND (p>0.05). However, the median follow-up was 34 months, presumably too short for addressing survival outcomes of prostate cancer.…”

Section: Cancer-specific and Overall Mortalitymentioning

confidence: 99%

The Benefits and Harms of Different Extents of Lymph Node Dissection During Radical Prostatectomy for Prostate Cancer: A Systematic Review

et al. 2017

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“…A recent systematic review and meta-analysis involving seven studies demonstrated that ePLND could provide oncological benefit for biochemical recurrence-free survival compared to sPLND 18 . Nevertheless, Nyushko and colleagues analyzed long-term outcomes of patients with localized PCa and reported no significant difference in CSS and OS between patients with ePLND and sPLND 19 . When compared to patients who did not receive PLND, no consensus has been reached to support the use of ePLND in terms of survival outcomes.…”

Section: Discussionmentioning

confidence: 99%

Pelvic lymph node dissection and its extent on survival benefit in prostate cancer patients with a risk of lymph node invasion >5%: a propensity score matching analysis from SEER database

Chen

Wang

Zhao

et al. 2019

Sci Rep

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Pelvic lymph node dissection (PLND) represents the gold standard for nodal staging in PCa and is recommended for patients with a probability of lymph node invasion (LNI) >5%. However, the therapeutic role of PLND and its extent remains a debate. In this study, data of 20,668 patients treated with radical prostatectomy (RP) with and without PLND from SEER database between 2010 and 2015 were retrospectively analyzed. All patients had a risk of LNI >5% according to 2012-Briganti nomogram. Propensity score matching (PSM) was performed to balance baseline characteristics between patients with and without PLND. Kaplan-Meier curves and Cox regression were used to evaluate the impacts of the PLND and its extent on cancer-specific survival (CSS) and overall survival (OS). In overall cohort, patients with PLND were associated with more aggressive clinicopathologic characteristics and had poorer survival compared to those without PLND (5-year CSS rate: 98.4% vs. 99.7%, p < 0.001; 5-year OS rate: 96.3% vs. 97.8%, p < 0.001). In the post-PSM cohort, no significant difference in survival was found between patients with and without PLND (5-year CSS rate: 99.4% vs. 99.7%, p = 0.479; 5-year OS rate: 97.3% vs. 97.8%, p = 0.204). In addition, the extent of PLND had no impact on prognosis (all p > 0.05). Subgroup analyses reported similar negative findings. In conclusion, neither PLND nor its extent was associated with survival in North American patients with a risk of LNI >5%. The cut-off point of 5% probability of LNI might be too low to show benefits in survival in patients underwent PLND.

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P066 Results of surgical treatment of localized and locally-advanced prostate cancer patients in subject to volume of lymph node dissection performed

Cited by 2 publications

References 0 publications

The Benefits and Harms of Different Extents of Lymph Node Dissection During Radical Prostatectomy for Prostate Cancer: A Systematic Review

The Benefits and Harms of Different Extents of Lymph Node Dissection During Radical Prostatectomy for Prostate Cancer: A Systematic Review

Pelvic lymph node dissection and its extent on survival benefit in prostate cancer patients with a risk of lymph node invasion >5%: a propensity score matching analysis from SEER database

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