P0643 Epidemiology of Ulcerative Colitis in Children in Southern Poland: Retrospective Study 1992???2002

Jedynak-Wąsowicz, Urszula; Wędrychowicz, Andrzej; Przybyszewska, Katarzyna; Fyderek, Krzysztof; Pieczarkowski, Stanisław; Sładek, M.; Al-Hutari, I.; Guła, Zofia

doi:10.1097/00005176-200406001-00767

Cited by 3 publications

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“…The incidence of IBD considerably increased in Western Europe and USA in children and adolescents during the last three decades while the age of manifestation of the disease symptoms decreased [ 5 , 6 ]. The results of the epidemiological studies carried out in the last years confirm similar trends in Poland [ 7 , 8 ].…”

Section: Introductionsupporting

confidence: 70%

Clinical value of serum eosinophilic cationic protein assessment in children with inflammatory bowel disease

Wędrychowicz¹,

Tomasik²,

Pieczarkowski³

et al. 2014

aoms

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IntroductionEosinophils contribute to the pathogenesis of inflammatory bowel disease (IBD) in the intestine. Eosinophilic cationic protein (ECP) is one of the most important eosinophilic specific mediators released during activation. The aim of the study was to evaluate the clinical value of serum ECP determination in children with active and inactive IBD and its correlation with disease activity.Material and methodsThere were 125 children with IBD (63 with Crohn's disease – CD, 44 with ulcerative colitis – UC, 18 indeterminate colitis – IC) enrolled in the study. Among them 83 children were in the active phase of the disease, while the remaining 42 were in remission. The control group consisted of 56 healthy children. The ECP was assessed three times in children with active IBD, at baseline and after 2 and 6 weeks of treatment and once in children with inactive IBD and controls using fluoroenzymeimmunoassays.ResultsWe found elevated ECP at baseline in the total active IBD group when compared to the inactive IBD and control groups, decreasing during treatment. Serum ECP was also elevated in the active UC and CD groups when compared to the inactive UC and CD groups, and correlated with clinical UC and CD activity (R = 0.57 and R = 0.52, p < 0.05, respectively) and duration of the clinical manifestation in UC (R = 0.62, p < 0.05) but not with the disease location in the gastrointestinal tract, or endoscopic and histopathological activity.ConclusionsEvaluation of serum ECP in children with IBD may be useful in disease activity assessment at onset and during the treatment.

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Section: Introductionsupporting

confidence: 70%

Clinical value of serum eosinophilic cationic protein assessment in children with inflammatory bowel disease

Wędrychowicz¹,

Tomasik²,

Pieczarkowski³

et al. 2014

aoms

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Wrzodziejące zapalenie jelita grubego u 2-letniego dziecka

et al. 2013

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Epidemiology of Inflammatory Bowel Disease among Children in Poland

et al. 2009

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Background/Aims: The incidence of pediatric inflammatory bowel disease (IBD) in Western countries is on the rise. No prospective studies have been conducted on the epidemiology of pediatric IBD in Poland. The aim of the study was to define the characteristics of new pediatric IBD and assess the incidence of new IBD among children in Poland between 2002 and 2004. Methods: Patient records from 24 pediatric gastroenterology centers servicing the whole population of Poland were collected. IBD diagnosis was based on clinical, radiological, endoscopic and histological features. Results: There were 491 new IBD patients, representing an overall incidence of IBD of 2.7 cases/100,000 children/year. The incidence of Crohn’s disease (CD) was 0.6, ulcerative colitis (UC) 1.3, and indeterminate colitis (IC) 0.8. The age-related incidence of IBD was 1.8 in the 0- to 10-year-old age group, rising to 3.7 for the 11- to 18-year age group. Conclusions: The overall incidence of IBD (as well as CD, UC and IC) in Poland is lower than that in Western countries. The relative contribution of UC and IC to the overall IBD incidence is higher in Poland than in most Western countries. These findings may suggest a tendency towards under- or misdiagnosis.

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P0643 Epidemiology of Ulcerative Colitis in Children in Southern Poland: Retrospective Study 1992???2002

Cited by 3 publications

References 0 publications

Clinical value of serum eosinophilic cationic protein assessment in children with inflammatory bowel disease

Clinical value of serum eosinophilic cationic protein assessment in children with inflammatory bowel disease

Wrzodziejące zapalenie jelita grubego u 2-letniego dziecka

Epidemiology of Inflammatory Bowel Disease among Children in Poland

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