P056 Pistacia atlantica, nouvelle substance utilisée contre le diabète associé au stress oxydant

Ziane, Nafissa; Dahamna, Saliha; Aouachria, Sana; Khanouf, S.; Harzallah, Daoud

doi:10.1016/s1262-3636(15)30169-5

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…STZ was dissolved in 0.1 M citrate buffer (pH 4.5) (Tadjeddine et al, 2013). Streptozotocin induces diabetes within 3 days by destroying the beta cells (Ziane et al, 2015). After 48 h of STZ administration, blood glucose level of each rat was determined (Anthikat et al, 2016).…”

Section: Induction Of Diabetesmentioning

confidence: 99%

Phytochemical and zootechnical studies of Physalis peruviana L. leaves exposured to streptozotocin-induced diabetic rats

Fokunang¹,

Mushagalusa²,

Tembe-Fokunang³

et al. 2017

J. Pharmacognosy Phytother.

View full text Add to dashboard Cite

This is a phytochemical and zootechnical study on Physalis peruviana leaves in streptozotocin induced diabetic rats. This was part of a scientific development program of plant resources used in Congolese traditional medicine for the treatment of diabetes mellitus in which individual and community consequences are well established. Different fractions with hexane, ethyl acetate and the residue were obtained from the hydroalcoholic extract of P. peruviana leaves. Phytochemical screening was focused on the usual reactions of characterization based on precipitation and coloration with general reagents. The diabetic conditions were induced in rats by a single administration of streptozotocin (50 mg/kg body weight) intravenously. The positive control group received glibenclamide (6.5 mg/kg body weight) and each test group received 100 mg/kg of body weight. Those groups were compared with a control group which received only a Tween 20 solution (1 ml per 100 g body weight). Zootechnical profiles were evaluated by weight monitoring as well as food and water consumption in rats. Phytochemical screening showed the presence of polyphenols, flavonoids, alkaloids, saponins, tannins, anthocyanins, mucilages, cardiac glycosides, coumarins and betalains in the hydroalcoholic extract and its fractions. A highly significant difference (P ˂ 0.001) of water consumption in opposition to the food intake and weight changes was observed. This study suggested the isolation and characterization of compounds from hydroalcoholic extract from the leaves of P. peruviana L. and its fractions for an extensive antidiabetic investigation.

show abstract

Section: Induction Of Diabetesmentioning

confidence: 99%

Phytochemical and zootechnical studies of Physalis peruviana L. leaves exposured to streptozotocin-induced diabetic rats

Fokunang¹,

Mushagalusa²,

Tembe-Fokunang³

et al. 2017

J. Pharmacognosy Phytother.

View full text Add to dashboard Cite

show abstract

“…STZ was dissolved in 0.1 M citrate buffer (pH 4.5) [17]. Streptozotocin induces diabetes within 3 days by destroying the beta cells [18]. After 48 hours of STZ administration, blood glucose level of each rat was determined [19].…”

Section: Induction Of Diabetesmentioning

confidence: 99%

Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from Physalis peruviana L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats

Kasali¹

2016

JDMP

View full text Add to dashboard Cite

The purpose of this study was to investigate the antidiabetic activity of extracts from leaves of Physalis peruviana L. used in the Eastern part of the Democratic Republic of the Congo used against diabetes. Different fractions with hexane, ethyl acetate and residue were obtained from the hydroalcoholic extract of Physalis peruviana leaves. The antidiabetic evaluation of hydroalcoholic and its fractions was evaluated in diabetic rats by a single administration of streptozotocin (50 mg/kg body weight) intravenously. The Reference group received glibenclamide (6.5 mg/kg body weight) and each test group received 100 mg/kg of body weight. Those groups were compared with a control group which received only a Tween 20 solution (1 ml per 100 g body weight). Serum biochemical profiles were evaluated by some blood markers including serum glucose, serum alanine transaminase (ALT), serum aspartate transaminase (AST) serum creatinine, total protein, triglyceride, total cholesterol, HDL-cholesterol and LDL-cholesterol. Antidiabetic profile evaluation showed no significant variation (P < 0.05) in blood glucose between groups after 28 days of treatment. There was no significant difference in the biochemical markers change including creatinine, ALT, AST, total protein, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol. The hydroalcoholic extract from the leaves of Physalis peruviana L. and its fractions showed antidiabetic activity suggesting future detailed studies for new chemical entities lead drug discovery.

show abstract

Utilisation des espèces du genre Aframomum (Aframomum aulacocorpus, A. citratum, A. daniellii) pour le contrôle du poids, le profil lipidique et le statut antioxydant chez les rats Wistar nourris avec une diète athérogène

Nguele¹,

Fokunang²,

Etoundie³

et al. 2017

Int. J. Bio. Chem. Sci

View full text Add to dashboard Cite

La génération des radicaux libres résultant de l'oxydation des lipides est l'un des problèmes associés à la perte des aliments et des maladies notamment celles liées au surpoids et à l'obésité. Les espèces oxygénées réactives telles que le radical hydroxyle et les hydroperoxydes sont généralement produites par des processus métaboliques normaux ou par des facteurs et agents externes. D'où l'objectif de rechercher de l'utilisation des espèces du genre Aframomum (Aframomum aulacocorpus, A. citratum, A. daniellii) Use of Aframomum species (Aframomum aulacocorpus, A. citratum, A. daniellii) for weight control, lipid profile and antioxidant status in Wistar rats fed an atherogenic diet ABSTRACT The generation of free radicals resulting from lipid oxidation is one of the problems associated with food loss and diseases mostly linked to overweight and obesity. The reactive oxygen species (ROS) such as the L. R. NGUELE et al. / Int. J. Biol. Chem. Sci. 10(6): 2575-2586 2576 hydroxy and the hydroxyperoxide radicals are generally produced by normal metabolic processes or by factors of external agents. This is the origin of the objective of this research in using three species of genus Aframomum (Aframomum aulacocorpus, A. citratum, A. daniellii) for weight control, lipid profile and antioxidant properties in wistar rats feed with atherogenic diet.The oral administration of hydroethanolic extracts of Aframomun aulacocorpus, A. citratum and A. daniellii reduced the exponential weight gain brought about by atherogenous diet. This was followed by a significant reduction (p<0.05) of total cholesterol and LDL cholesterol, with a significant increase (p<0.05) of HDL cholesterol. The extract also had a significant reduction (p<0.05) in the concentration of hydroperoxide and malondialdehyde (MDA) by increasing the antioxidant status of the experimental animals.

show abstract

P056 Pistacia atlantica, nouvelle substance utilisée contre le diabète associé au stress oxydant

Cited by 3 publications

References 0 publications

Phytochemical and zootechnical studies of Physalis peruviana L. leaves exposured to streptozotocin-induced diabetic rats

Phytochemical and zootechnical studies of Physalis peruviana L. leaves exposured to streptozotocin-induced diabetic rats

Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from <i>Physalis peruviana</i> L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats

Utilisation des espèces du genre <i>Aframomum</i> (<i>Aframomum aulacocorpus, A. citratum, A. daniellii</i>) pour le contrôle du poids, le profil lipidique et le statut antioxydant chez les rats Wistar nourris avec une diète athérogène

Contact Info

Product

Resources

About

P056 Pistacia atlantica, nouvelle substance utilisée contre le diabète associé au stress oxydant

Cited by 3 publications

References 0 publications

Phytochemical and zootechnical studies of Physalis peruviana L. leaves exposured to streptozotocin-induced diabetic rats

Phytochemical and zootechnical studies of Physalis peruviana L. leaves exposured to streptozotocin-induced diabetic rats

Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from &lt;i&gt;Physalis peruviana&lt;/i&gt; L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats

Utilisation des espèces du genre <i>Aframomum</i> (<i>Aframomum aulacocorpus, A. citratum, A. daniellii</i>) pour le contrôle du poids, le profil lipidique et le statut antioxydant chez les rats Wistar nourris avec une diète athérogène

Contact Info

Product

Resources

About

Evaluation of the Antidiabetic Properties of Hydro-Alcoholic Extract and Its Fractions from <i>Physalis peruviana</i> L. Leaves on Streptozotocin-Induced Diabetic Wistar Rats