P045 Occupational exposure and prostate cancer in the multicase-control study in spain (MCC-„spain)

Abstract

BackgroundIn Spain, prostate cancer is the third cause of mortality from cancer in men, after lung and colorectal cancers. Age, family history and race are common risk factors. Several environmental and occupational factors have been investigated, including pesticides and endocrine disruptors, but results are inconsistent. We have previously shown an association of prostate cancer risk with shift work. We evaluate here which occupations and agents are associated with a high risk for prostate cancer within the framework of the MCC-Spain.MethodsWe included 1111 incident cases of prostate cancer and 1489 population controls recruited from 7 Spanish regions from September 2008 to December 2012. Occupational history was collected for all subjects, and occupations were coded according to the Spanish National Classification of Occupations 1994 (CNO-94). The Spanish Job Exposure Matrix (MatEmESp) was applied to assess occupational exposures to different agents. Unconditional logistic regression was applied, adjusting for age, education and region, showing Odds Ratios and 95% Confidence Intervals (OR; CI).ResultsConstruction building managers (OR = 2.0; 1.1–3.8), cleaning personnel (OR = 2.1; 1.1–4.0), farmers (OR = 3.0; 1.1–8.1) were associated with an increase risk in prostate cancer. An association has been observed for exposure to inorganic dust, specifically to silica dust (OR = 1.3; 1.1–1.7), insecticides (OR = 1.4; 1.1–1.8), and ultraviolet radiations (OR = 1.3; 1.1–1.6). Analysis on intensity and duration of the exposure to certain agents as well as associations with extension of the disease will be presented.ConclusionsOccupational exposures may play a role in the development of prostate cancer.