Abstract:*authors contributed equally INTRODUCTION: The treatment of glioblastoma multiforme (GBM) is a major challenge of neuro-oncology. Despite aggressive therapeutic strategies including surgery and radio-chemotherapy, median survival remains extremely low. This points to the urgent need for alternative treatment strategies such as immunotherapy. Immunological escape mechanisms, involving the Natural Killer Group 2, member D (NKG2D) receptor-ligand system, play a major role in tumor progression. Cell-bound NKG2D-li… Show more
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