P029 Effects of dual-mode non-invasive brain stimulation on freezing of gait in patients with Parkinson’s disease

Effectiveness of Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in Parkinson's Disease Patients: A Systematic Review of the Literature

“…Dagan and colleague study [32] were the sole study to stimulate the mPFC and no significant improvement on FoG-Q score, with significant improvement in UPDRS III scores; no previous trials for effect of mPFC stimulation on FOG, and only previous literature [33,34] suggest a role in FOG pathophysiology. The dual-mode non-invasive brain stimulation (NIBS) involves simultaneous rTMS and tDCS stimulation had shown greater degree of improvement in terms of FOG-Q outcome compared to rTMS alone in previous studies [35,36], possibly due to their synergistic effect, and whether it should be implemented as superior technique to rTMS alone needs further studies. Another approach never implemented in the included studies is the neuro-navigational approach using MRI scan, while previous studies [37,38] showed enhanced responses to rTMS treatment in setting of the use of neuro-navigational methods to target a specific site.…”

The effects of anodal tDCS over the supplementary motor area on gait initiation in Parkinson’s disease with freezing of gait: a pilot study

“…Recent studies have examined the effects of tDCS, applied to either the primary motor cortex alone, or in combination with stimulation of prefrontal regions involved in executive function, on motor behavior and freezing in people with PD [30][31][32]. These studies showed that single [30] or repeated sessions [31,32] can reduce the incidence and duration FOG episodes and the time to complete timed up-and-go tasks. In particular, combined primary motor and dorsolateral prefrontal stimulation showed the most consistent results across subjects at reducing FOG events [30].…”