P0131 Efficacy of gum arabic-conjugated gold nanoparticles as a photothermal therapy for lung cancer: In vitro and in vivo approaches

Gamal‐Eldeen, Amira M.; Moustafa, Dina; El‐Daly, Sherien M.; Katti, Kattesh V.

doi:10.1016/j.ejca.2014.03.175

Cited by 4 publications

(3 citation statements)

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“…The difference in the ability for specific tumor targeting of these two derivatives has been investigated, and the disaccharide motif was found to be responsible for selective binding to MCF-7 human breast carcinoma cells and BxPC-3 pancreatic cancer cells, while having their healthy counterparts not being targeted. 145 Hyaluronic acid is a polysaccharide distributed widely in all tissues and body fluids of vertebrates and is most abundantly found in the connective tissues, serves many physiological functions, including lubrication, filtering, water homeostasis, and regulation of plasma protein distribution. Furthermore, after coupling of the disaccharide moiety to the surface of microbubbles ( Table 1, entry 8), which consist of an empty core and a lipid shell, and originally used as contrast agents for ultrasonography, 128 specific targeting of MCF-7 human breast carcinoma cells has been observed.…”

Section: Carbohydrate-functionalized Nanocarriersmentioning

confidence: 99%

“…In another work, in vivo studies of gum Arabic functionalized GNP resulted in significant alterations in lung tumors in mice upon laser irradiation, including cyto-toxicity, apoptosis, decreased inflammation and angiogenesis, and enhanced lipid peroxidation. 145 Hyaluronic acid is a polysaccharide distributed widely in all tissues and body fluids of vertebrates and is most abundantly found in the connective tissues, serves many physiological functions, including lubrication, filtering, water homeostasis, and regulation of plasma protein distribution. It is metabolized by receptor-mediated endocytosis, and subsequent lysosomal degradation.…”

Section: Carbohydrate-functionalized Nanocarriersmentioning

confidence: 99%

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Carbohydrate nanocarriers in biomedical applications: functionalization and construction

et al. 2015

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The specific targeting of either tumor cells or immune cells in vivo by carefully designed and appropriately surface-functionalized nanocarriers may become an effective therapeutic treatment for a variety of diseases. Carbohydrates, which are prominent biomolecules, have shown their outstanding ability in balancing the biocompatibility, stability, biodegradability, and functionality of nanocarriers. The recent applications of sugar (mono/oligosaccharides and/or polysaccharides) for the development of nanomedicines are summarized in this review, including the application of carbohydrates for the surface-functionalization of various nanocarriers and for the construction of the nanocarrier itself. Current problems and challenges are also addressed.

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Section: Carbohydrate-functionalized Nanocarriersmentioning

confidence: 99%

Section: Carbohydrate-functionalized Nanocarriersmentioning

confidence: 99%

Carbohydrate nanocarriers in biomedical applications: functionalization and construction

et al. 2015

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“…Incorporation of gum arabic on the gold nanoparticulate surface affords optimum in vitro and in vivo stability against agglomeration under the complex biological in vivo conditions. 2,14,15,[18][19][20][54][55][56][57][58][59] As we have utilized nanotechnology to encapsulate Ayurvedically-relevant phytochemicals from Y. filamentosa, we have coined the term nano-Ayurvedic medicine for this medical approach. The US Patents and Trademarks office has recently granted the first ever patent for our invention on nano-Ayurvedic medicine.…”

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confidence: 99%

Green Nanotechnology of Yucca filamentosa- Phytochemicals-Functionalized Gold Nanoparticles—Antitumor Efficacy Against Prostate and Breast Cancers

Thipe,

Jatar,

Raphael Karikachery

et al. 2023

NSA

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We report an innovative green nanotechnology utilizing an electron-rich cocktail of phytochemicals from Yucca filamentosa L. to synthesize biocompatible gold nanoparticles without the use of any external chemical reducing agents and evaluate their anticancer activity. Methods: Yucca filamentosa L. extract, containing a cocktail of phytochemicals, was prepared, and used to transform gold salt into Y. filamentosa phytochemicals encapsulated gold nanoparticles (YF-AuNPs). Additionally, gum arabic stabilized YF-AuNPs (GAYF-AuNPs) were also prepared to enhance the in vitro/in vivo stability. Anticancer activity was evaluated against prostate (PC-3) and breast (MDAMB-231) cancer cell lines. Targeting abilities of gold nanoparticles were tested using pro-tumor macrophage cell lines. Results: Comprehensive characterization of new nanomedicine agents YF-AuNPs and GAYF-AuNPs revealed spherical, and monodisperse AuNPs with moderate zeta potentials (−19 and −20 mV, respectively), indicating in vitro/in vivo stability. The core size of YF-AuNPs (14 ± 5 nm) and GAYF-AuNPs (10 ± 5 nm) is suitable for optimal penetration into tumor cells through both enhanced permeability and retention (EPR) effect as well as through the receptor mediated endocytosis. Notably, YF-AuNPs exhibited potent anticancer activity against prostate (PC-3) and breast tumors (MDAMB-231) by inducing early and late apoptotic stages. Moreover, YF-AuNPs resulted in elevated levels of anti-tumor cytokines (TNF-α and IL-12) and reduced levels of pro-tumor cytokines (IL-6 and IL-10), provide compelling evidence on the immunomodulatory property of YF-AuNPs. Conclusion:Overall, these Y. filamentosa phytochemicals functionalized nano-Ayurvedic medicine agents demonstrated selective toxicity to cancer cells while sparing normal cells. Most notably, to our knowledge, this is the first study that shows YF-AuNP's targeting efficacy toward pro-tumor macrophage cell lines, suggesting an immunomodulatory pathway for cancer treatment. This work introduces a novel avenue for herbal and nano-Ayurvedic approaches to human cancer treatment, mediated through selective efficacy and immunomodulatory potential.

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Gum-based nanoparticles in cancer therapy

Amaldoss

Reeta

2022

Micro- And Nanoengineered Gum-Based Biomaterials for Drug Delivery and Biomedical Applications

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P0131 Efficacy of gum arabic-conjugated gold nanoparticles as a photothermal therapy for lung cancer: In vitro and in vivo approaches

Cited by 4 publications

References 0 publications

Carbohydrate nanocarriers in biomedical applications: functionalization and construction

Carbohydrate nanocarriers in biomedical applications: functionalization and construction

Green Nanotechnology of Yucca filamentosa- Phytochemicals-Functionalized Gold Nanoparticles—Antitumor Efficacy Against Prostate and Breast Cancers

Gum-based nanoparticles in cancer therapy

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