P0084 Pp a Mixture of Galacto and Fructo Oligosaccharides Shows Prebiotic Effects and Enhances Systemic Cellular Immune Responsiveness in Mice.

Vos, Anneke S. de; Buco, A.; Haarman, Monique; Knol, Jan; Govers, Mirjam J.A.P.; Stahl, Bernd; Boehm, G; Garssen, J.; Rabet, L M

doi:10.1097/00005176-200406001-00208

Cited by 5 publications

(7 citation statements)

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“…The effect was less pronounced when the nutritional intervention started on the same day as the first vaccination. No significant effect was achieved when the nutritional intervention started after the first vaccination [31]. These data suggest that dietary galacto-/fructo-oligosaccharides can improve the Th1mediated response to vaccination, even if the effect needs a period of adaptation.…”

Section: Effect Of Dietary Prebiotic Galacto-and Fructo-oligosaccharimentioning

confidence: 78%

“…ILSI and WHO also recommend using well-defined mouse models for the experimental part of proving an effect of an ingredient on the immune system [30]. Because the models are designed for pharmaceutical studies, we adopted the model according to our hypothesis [31].…”

Section: Effect Of Dietary Prebiotic Galacto-and Fructo-oligosaccharimentioning

confidence: 99%

“…The effect of dietary galacto-/fructo-oligosaccharides on the Th1-mediated response to vaccination, as alternative for infection studies, has been studied in the respective mouse model [31]. The data demonstrate a significant increase in the immune response when feeding animals a galacto-/fructo-oligosaccharidessupplemented diet compared to a standard diet.…”

Section: Effect Of Dietary Prebiotic Galacto-and Fructo-oligosaccharimentioning

confidence: 99%

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Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: A review

Fanaro

Boehm²,

Garssen³

et al. 2005

Acta Paediatrica

133

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Section: Effect Of Dietary Prebiotic Galacto-and Fructo-oligosaccharimentioning

confidence: 78%

Section: Effect Of Dietary Prebiotic Galacto-and Fructo-oligosaccharimentioning

confidence: 99%

Section: Effect Of Dietary Prebiotic Galacto-and Fructo-oligosaccharimentioning

confidence: 99%

See 1 more Smart Citation

Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: A review

Fanaro

Boehm²,

Garssen³

et al. 2005

Acta Paediatrica

133

View full text Add to dashboard Cite

show abstract

“…ILSI and WHO also recommend using well‐defined mouse models for the experimental part of proving an effect of an ingredient on the immune system 30. Because the models are designed for pharmaceutical studies, we adopted the model according to our hypothesis 31.…”

Section: Effect Of Dietary Prebiotic Galacto‐ and Fructo‐oligosaccharmentioning

confidence: 99%

“…The effect of dietary galacto‐/fructo‐oligosaccharides on the Th1‐mediated response to vaccination, as alternative for infection studies, has been studied in the respective mouse model 31. The data demonstrate a significant increase in the immune response when feeding animals a galacto‐/fructo‐oligosaccharides‐supplemented diet compared to a standard diet.…”

Section: Effect Of Dietary Prebiotic Galacto‐ and Fructo‐oligosaccharmentioning

confidence: 99%

Galacto‐oligosaccharides and long‐chain fructo‐oligosaccharides as prebiotics in infant formulas: A review

Fanaro

Boehm²,

Garssen³

et al. 2005

Acta Paediatrica

122

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The present review summarizes clinical and experimental data concerning the possible effects of a prebiotic mixture of short‐chain galacto‐oligosaccharides and long‐chain fructo‐oligosaccharides. The results from several studies, made up of over 400 preterm and term infants, clearly demonstrate that the prebiotic mixture under examination specifically stimulates the growth of bifidobacteria and lactobacilli and reduces the growth of pathogens. As a consequence of the changed intestinal flora by the dietary galacto‐oligosaccharides and fructo‐oligosaccharides, the faecal pH values and the short‐chain fatty acid pattern were similar to those found in breastfed infants. In addition, the stool consistency was the same as in breastfed infants. In vitro experiments have demonstrated that the specific short‐chain fatty acid pattern, at a pH similar to that found in faecal samples of breastfed infants, reduces the growth of pathogens in a dose‐dependent manner but does not influence the growth of bifidobacteria and lactobacilli. In an animal vaccination model, the prebiotic mixture improved the response to vaccination. In an allergy model (sensitization by ovalbumin), the allergic reaction was reduced by the prebiotic mixture. The data obtained from animal experiments are in agreement with preliminary data from clinical trials which indicate a reduced allergic response (reduced plasma IgE/IgG4 ratio) and reduced episodes of upper airway infection during the first year of life. Conclusion: Experimental evidence demonstrates that the prebiotic mixture employed in these studies modulates the intestinal flora and modulates the immune system as human milk does. There are sufficient experimental data to put forward the hypothesis that substances like the prebiotic mixture under study will substantially contribute to the improvement of the protective properties of infant formulas.

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The effect of a prebiotic supplemented formula on growth and stool microbiology of term infants

Costalos

Kapiki

Apostolou

et al. 2008

Early Human Development

124

116

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P0084 Pp a Mixture of Galacto and Fructo Oligosaccharides Shows Prebiotic Effects and Enhances Systemic Cellular Immune Responsiveness in Mice.

Cited by 5 publications

References 0 publications

Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: A review

Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: A review

Galacto‐oligosaccharides and long‐chain fructo‐oligosaccharides as prebiotics in infant formulas: A review

The effect of a prebiotic supplemented formula on growth and stool microbiology of term infants

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