P002 Sero-Reactivity to Microbial Components in Crohn's Disease Is Associated With Ileal Involvement, Non-Inflammatory Disease Behaviour and Nod2/Card15 Genotype, but Not Response to Medical Therapy or Risk for Surgery

Papp, Mária; Altorjay, I; Norman, G.L.; Palatka, Károly; Lakos, Gabriella; Fischer, Simon; Lakatos, Lajos; Bene, László; Molnár, Tamás; Tulassay, Zsolt; Miheller, Pál; LakatosL, P.

doi:10.1016/s1873-9954(07)70014-9

Cited by 3 publications

(17 citation statements)

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“…In previous studies the sensitivity, specificity, and PPV values for the markers ranged from 80.5%-99.1% for the differentiation between CD, UC, and controls. The combination of ASCA/pANCA 19 or gASCA/pANCA 22 were associated with the best predictive values; however, sensitivity was only around 50%-60%. The combination of anti-glycan antibodies and pANCA only slightly improved the sensitivity compared to gASCA or the combination of gASCA and pANCA.…”

Section: Discussionmentioning

confidence: 89%

“…Furthermore, we tested the diagnostic accuracy of combining markers. ASCA, pANCA, Omp, 5,7,[17][18][19] and anti-glycan antibodies 21,22 are well-accepted serological markers in IBD, predicting complicated disease. In previous studies the sensitivity, specificity, and PPV values for the markers ranged from 80.5%-99.1% for the differentiation between CD, UC, and controls.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, in another European study, increased prevalence of PAB was observed in patients with stricturing or penetrating phenotypes. 15 In addition, anti-Saccharomyces cerevisiae antibodies (ASCAs) are primarily associated with CD, 16,17 while perinuclear, DNaseI sensitive, "atypical" anti-neutrophil cytoplasmic antibodies (pANCA) 5,7,18,19 are mainly associated with UC and may be of importance in differentiating between UC and CD. Antibodies directed against the outer membrane porin protein C of Escherichia coli (antiOmpC) 19,23,26 were also reported in CD patients.…”

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confidence: 99%

“…Ferrante et al 21 as well as our group 22 reported that the presence and magnitude of the serological response to this new panel of antibodies was associated with complicated disease, disease duration, and need for surgery. Furthermore, the presence of "conventional" serological markers could be used for disease stratification and were associated with a more aggressive disease phenotype 19,23,24 and a risk for surgery 25,26 also in pediatric patients, 27,28 respectively.…”

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confidence: 99%

“…However, studies investigating the relationship between ASCA and NOD2/CARD15 status in CD have produced partly conflicting results. 19,23,29 The aim of our multicenter study was to assess the prevalence and staining patterns of PAB and GAB antibodies in a large cohort of Hungarian IBD patients and to study their accuracy in the diagnosis and differential diagnosis of IBD as well as the possible interaction with the clinical presentation, response to treatment, and extraintestinal manifestations. We also aimed to study the relationship between serological response and genetic factors.…”

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confidence: 99%

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Pancreatic Autoantibodies Are Associated with Reactivity to Microbial Antibodies, Penetrating Disease Behavior, Perianal Disease, and Extraintestinal Manifestations, But Not with NOD2/CARD15 or TLR4 Genotype in a Hungarian IBD Cohort

Lakatos¹,

Altorjay²,

Szamosi³

et al. 2009

Inflammatory Bowel Diseases

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Pancreatic Autoantibodies Are Associated with Reactivity to Microbial Antibodies, Penetrating Disease Behavior, Perianal Disease, and Extraintestinal Manifestations, But Not with NOD2/CARD15 or TLR4 Genotype in a Hungarian IBD Cohort

Lakatos¹,

Altorjay²,

Szamosi³

et al. 2009

Inflammatory Bowel Diseases

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Interaction between seroreactivity to microbial antigens and genetics in Crohn’s disease: is there a role for defensins?

Altorjay

Mándi

et al. 2008

Tissue Antigens

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Antibodies against different microbial epitopes are associated with disease phenotype, may be of diagnostic importance and may reflect a loss of tolerance in Crohn's disease (CD). Recently, an association was reported between the presence of these antibodies and mutations in pattern receptor genes. Our aim was to investigate whether mutations in various genes other than NOD2/CARD15 or TLR4 associated with CD (NOD1/CARD4, DLG5 and DEFB1) may influence the presence of antibodies against bacterial proteins and carbohydrates in a Hungarian cohort of CD patients. Three hundred and seventy-six well-characterized, unrelated, consecutive CD patients (male/female: 191/185, age at onset: 29.1 +/- 12.9 years, duration: 7.9 +/- 11.7 years) were investigated. Sera were assayed for anti-Omp, anti-Saccharomyces cerevisiae antibodies (ASCAs) immunoglobulin (Ig) A and IgG, and antibodies against a mannan epitope of S. cerevisiae (gASCA), laminaribioside (ALCA), chitobioside (ACCA), and mannobioside (AMCA). NOD1/CARD4, DLG5 and DEFB1 variants were tested by polymerase chain reaction-restriction fragment length polymorphism, and DEFB1 was genotyped in a subgroup of 160 patients. Detailed clinical phenotypes were determined by reviewing the patients' medical charts. The carriage of DEFB1 20A variant alleles less frequently led to antiglycan positivity compared with patients without (29.6% vs 46.2%, OR: 0.49, 95% CI: 0.25-0.97), regardless of disease location or behavior. Similar tendency was observed for DEFB1 44G (present: 21.6% vs absent: 10.2%, P = 0.06) and ALCA. A gene or serology dosage effect was not observed. However, no association was found between the DEFB1 G52A, DLG5 R30Q, and NOD1/CARD4 E266K variants and any of the serology markers. We found that variants in human beta-defensin 1 gene are inversely associated with antiglycan antibodies, further confirming an important role for innate immunity in the pathogenesis of CD.

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New Serological Markers for Inflammatory Bowel Disease Are Associated With Earlier Age at Onset, Complicated Disease Behavior, Risk for Surgery, and NOD2/CARD15 Genotype in a Hungarian IBD Cohort

Papp¹,

Altorjay²,

Dotan³

et al. 2008

The American Journal of Gastroenterology

130

154

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P002 Sero-Reactivity to Microbial Components in Crohn's Disease Is Associated With Ileal Involvement, Non-Inflammatory Disease Behaviour and Nod2/Card15 Genotype, but Not Response to Medical Therapy or Risk for Surgery

Cited by 3 publications

References 0 publications

Pancreatic Autoantibodies Are Associated with Reactivity to Microbial Antibodies, Penetrating Disease Behavior, Perianal Disease, and Extraintestinal Manifestations, But Not with NOD2/CARD15 or TLR4 Genotype in a Hungarian IBD Cohort

Pancreatic Autoantibodies Are Associated with Reactivity to Microbial Antibodies, Penetrating Disease Behavior, Perianal Disease, and Extraintestinal Manifestations, But Not with NOD2/CARD15 or TLR4 Genotype in a Hungarian IBD Cohort

Interaction between seroreactivity to microbial antigens and genetics in Crohn’s disease: is there a role for defensins?

New Serological Markers for Inflammatory Bowel Disease Are Associated With Earlier Age at Onset, Complicated Disease Behavior, Risk for Surgery, and NOD2/CARD15 Genotype in a Hungarian IBD Cohort

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