P wave duration and dispersion in Holter electrocardiography of patients with obstructive sleep apnea

Jazi, Mohammad Hashemi; Amra, Babak; Yazdchi, Mohammadreza; Jahangiri, Mansour; Tabesh, Faezeh; Gholamrezaei, Ali

doi:10.1007/s11325-013-0917-1

Cited by 7 publications

(2 citation statements)

References 25 publications

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“…Obstructive sleep apnoea patients exhibit cardiac electrophysiological changes [36][37][38][39], and we also found that P wave durations and T wave amplitudes were increased after 2 weeks of chronic OSA. For comparison, Baranchuk et al [39] showed that the longer signal averaged P wave durations seen in OSA patients could be decreased with continuous positive airway pressure.…”

Section: Discussionsupporting

confidence: 67%

Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea

Channaveerappa

Lux

Wormwood

et al. 2017

J Cellular Molecular Medi

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Obstructive sleep apnoea (OSA) affects 9–24% of the adult population. OSA is associated with atrial disease, including atrial enlargement, fibrosis and arrhythmias. Despite the link between OSA and cardiac disease, the molecular changes in the heart which occur with OSA remain elusive. To study OSA‐induced cardiac changes, we utilized a recently developed rat model which closely recapitulates the characteristics of OSA. Male Sprague Dawley rats, aged 50–70 days, received surgically implanted tracheal balloons which were inflated to cause transient airway obstructions. Rats were given 60 apnoeas per hour of either 13 sec. (moderate apnoea) or 23 sec. (severe apnoea), 8 hrs per day for 2 weeks. Controls received implants, but no inflations were made. Pulse oximetry measurements were taken at regular intervals, and post‐apnoea ECGs were recorded. Rats had longer P wave durations and increased T wave amplitudes following chronic OSA. Proteomic analysis of the atrial tissue homogenates revealed that three of the nine enzymes in glycolysis, and two proteins related to oxidative phosphorylation, were down regulated in the severe apnoea group. Several sarcomeric and pro‐hypertrophic proteins were also up regulated with OSA. Chronic OSA causes proteins changes in the atria which suggest impairment of energy metabolism and enhancement of hypertrophy.

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Section: Discussionsupporting

confidence: 67%

Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea

Channaveerappa

Lux

Wormwood

et al. 2017

J Cellular Molecular Medi

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“…4,5 The prolongation of P-wave dispersion (Pd) has been observed in adult patients with adenotonsillar hypertrophy and obstructive sleep apnea (OSA). 6,7 However, the risk of arrhythmia in NSD patients has not been studied in detail.…”

mentioning

confidence: 99%

Effects of Nasal Septum Deviation and Septoplasty on Cardiac Arrhythmia Risk

Uluyol

Kılıçaslan

Gür

et al. 2016

Otolaryngol.--head neck surg.

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Noninvasive evaluation of reverse atrial remodeling after catheter ablation of atrial fibrillation by P wave dispersion

et al. 2017

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Atrial fibrillation (AF) itself creates structural and electrophysiological changes such as atrial enlargement, shortening of refractory period and decrease in conduction velocity, called "atrial remodeling", promoting its persistence. Although the remodeling process is considered to be reversible, it has not been elucidated in detail. The aim of this study was to assess the feasibility of P wave dispersion in the assessment of reverse atrial remodeling following catheter ablation of AF. Consecutive 126 patients (88 males, age 63.0 ± 10.4 years) who underwent catheter ablation for paroxysmal AF were investigated. P wave dispersion was calculated from the 12 lead ECG before, 1 day, 1 month, 3 months and 6 months after the procedure. Left atrial diameter (LAD), left atrial volume index (LAVI), left ventricular ejection fraction (LVEF), transmitral flow velocity waveform (E/A), and tissue Doppler (E/e') on echocardiography, plasma B-type natriuretic peptide (BNP) concentrations, serum creatinine, and estimated glomerular filtration rate (eGFR) were also measured. Of all patients, 103 subjects remained free of AF for 1 year follow-up. In these patients, P wave dispersion was not changed 1 day and 1 month after the procedure. However, it was significantly decreased at 3 and 6 months (50.1 ± 14.8 to 45.4 ± 14.4 ms, p < 0.05, 45.2 ± 9.9 ms, p < 0.05, respectively). Plasma BNP concentrations, LAD and LAVI were decreased (81.1 ± 103.8 to 44.8 ± 38.3 pg/mL, p < 0.05, 38.2 ± 5.7 to 35.9 ± 5.6 mm, p < 0.05, 33.3 ± 14.2 to 29.3 ± 12.3 mL/m, p < 0.05) at 6 months after the procedure. There were no significant changes in LVEF, E/A, E/e', serum creatinine, and eGFR during the follow up period. P wave dispersion was decreased at 3 and 6 months after catheter ablation in patients without recurrence of AF. P wave dispersion is useful for assessment of reverse remodeling after catheter ablation of AF.

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P wave duration and dispersion in Holter electrocardiography of patients with obstructive sleep apnea

Cited by 7 publications

References 25 publications

Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea

Atrial electrophysiological and molecular remodelling induced by obstructive sleep apnoea

Effects of Nasal Septum Deviation and Septoplasty on Cardiac Arrhythmia Risk

Noninvasive evaluation of reverse atrial remodeling after catheter ablation of atrial fibrillation by P wave dispersion

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