P. vivax Malaria and Dengue Fever Co-infection: A Cross-Sectional Study in the Brazilian Amazon

Magalhães, Belisa Maria Lopes; Siqueira, André Machado; Alexandre, Márcia A. A.; Souza, Marcela Santos de; Gimaque, João Bosco Lima; Bastos, Michele Souza; Figueiredo, Regina Maria Pinto de; Melo, Gisely Cardoso de; Lacerda, Marcus; Mourão, Maria Paula Gomes

doi:10.1371/journal.pntd.0003239

Cited by 57 publications

(106 citation statements)

References 29 publications

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“…Nevertheless, there was a significant association between co-infection group and both mono-infection groups with hospitalized patients (p < 0.05). Almost Similar findings were seen in studies by Epelboin et al [11] and Magalhães et al [22], who found that the duration of fever was longer in co-infection patients and they were hospitalized more frequently than malaria and dengue monoinfection.…”

Section: Discussionsupporting

confidence: 88%

Epidemiological Characteristic of Malaria Coinfected with Dengue Fever in Hodeidah, Yemen

Al-Areeqi

Alghalibi

Yusuf

et al. 2020

IJTDH

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Introduction: Malaria and dengue fever are the most prevalent vector-borne diseases in tropical areas and represent major public health problems. They are transmitted by mosquito namely Anopheles and Aedes aegypti, respectively. Hodeidah is a high density with these vectors. Also, co-infection of these diseases has (malaria and dengue) become undetected due to lack of suspicious clinical suspicion and overlapping symptoms. Aim of the Study:The study aimed to detect the prevalence of co-infection with malaria and dengue fever, determine the clinical presentation within febrile patients in Hodeidah city and determine some potential risk factors associated with co-infection. Methods: A cross-sectional study was conducted (from January to December 2017) in febrile patients. All patients were designed into three groups: Group A (co-infected with malaria and dengue); Group B (malaria as mono-infection) and Group C (dengue as mono-infection). The diagnosis of malaria was by microscopic and rapid diagnostic test (RDT) and the dengue virus was Al-Areeqi et al.; IJTDH, 40(3): 1-10, 2019; Article no.IJTDH.54064 2 detected using enzyme-linked immunosorbent assay (ELISA). The diagnosis was performed in Center of Tropical Medicine and Infectious Diseases (CTMID), Authority of AL-Thawra Public Hospital-Hodeidah, in collaboration with the Tihama Foundation for Medical-Pharmaceutical Studies and Research (TFMPSR), Hodeidah, Yemen. Results: Out of 270 febrile patients, 82 cases (30.4%) patients were malaria -dengue coinfection, 100 cases (37.0%) of malaria, 21 cases (7.7%) of dengue and 67 cases (24.8%) were non-malaria and non-dengue. The most common symptoms were fever, headache, arthralgia, myalgia and retro-orbital pain, where the clinical symptoms of co-infected patients were more like dengue than malaria. One death was reported in malaria -dengue coinfection, with a case fatality rate (CFR%) of 1.2% (1/82). Conclusion: Our results show a high prevalence of malaria -dengue coinfecion in Hodeidah, Yemen as the first time. These due to a high density of vectors in this region and endemic areas for malaria and dengue. Furthermore, surveillance strategies, preventive measures and healthcare worker's education are critical for curtailing this problem and lifesaving. Original Research Article

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Section: Discussionsupporting

confidence: 88%

Epidemiological Characteristic of Malaria Coinfected with Dengue Fever in Hodeidah, Yemen

Al-Areeqi

Alghalibi

Yusuf

et al. 2020

IJTDH

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“…Previous studies have described dual infections of Plasmodium and other arboviruses including DENV or CHIKV [2][3][4] . But co-infections with 3 different pathogens are rarely reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Concurrent Infection with <b><i>Plasmodium vivax</i></b> and the Dengue and Chikungunya Viruses in a Paediatric Patient from New Delhi, India in 2016

et al. 2017

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Dengue and chikungunya fevers are transmitted by the common mosquito vector Aedes and malaria by Anopheles. Concurrent infections are reported due to co-circulation of these pathogens, especially in endemic regions. We report a rare case of triple infection with 3 arthropod-borne pathogens (Plasmodium vivax and the dengue and chikungunya viruses) in a 3-year-old child from New Delhi, India, in August 2016. The viruses were identified by RT-PCR and the parasite by microscopy and antigen detection. The dengue virus serotype 3 sequence was clustered in the genotype III by the phylogenetic analysis. Mixed infection with multiple pathogens is a challenge for accurate diagnosis due to the overlapping clinical symptoms. The accurate and timely diagnosis of multiple pathogens in such cases is important for rapid and effective patient management.

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“…Although infection with Dengue or malaria can be life‐threatening, co‐infections with DENV and malaria could be more severe . Owing to the similar symptoms common to DENV‐ and malaria‐infected individuals, misdiagnosis of either, and/or co‐infections have informed the need for a differential diagnostic approach especially in DENV‐/malaria‐endemic regions . This study sought to investigate the incidence of co‐infections with DENV and malaria parasites in Ilorin, Nigeria, as well as the immunological status of febrile subjects against DENV infections in Ilorin, Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Dengue virus and malaria concurrent infection among febrile subjects within Ilorin metropolis, Nigeria

Kolawole

Seriki

Irekeola

et al. 2017

Journal of Medical Virology

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Dengue is a mosquito‐borne disease of public health importance. It is caused by four serotypes of Dengue virus (i.e, DENV‐1, ‐2, ‐3, and ‐4). As a result of practices that are conducive for mosquito breading, its vector is widespread in Nigeria and this could result to possible DENV outbreaks in Nigeria and beyond. This study aimed to assess the recency of DENV infection as well as occurrence of DENV and Malaria co‐infections within Ilorin, Nigeria. Blood samples were obtained from 176 febrile subjects and analyzed using Enzyme Linked Immunosorbent Assay (ELISA) for the presence of DENV antibodies. Malaria infection was detected using a rapid diagnostic test kit for malaria parasites. Malaria and DENV (IgM positive) co‐infected samples were further subjected to RT‐qPCR analysis. A seroprevalence of 46.0% was recorded for anti‐DENV IgM antibodies and 2.84% for concurrent Dengue and malaria infections. Out of 95 IgM negative samples, 48 were found to be positive for DENV IgG antibodies. Eleven (6.25%) samples were confirmed DENV positive following RT‐qPCR. The CT values of the amplicons were between 19.0 and 20.0. DENV serotype 2 dominated the study, while serotype 3 and 4 were equally distributed. Based on the high seroprevalence of DENV obtained in this study, there is a high possibility of experiencing Dengue virus outbreak in Ilorin, Nigeria, not neglecting the fast geographical spread of the vector. Therefore, surveillance and intensive vector control program should be instituted.

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P. vivax Malaria and Dengue Fever Co-infection: A Cross-Sectional Study in the Brazilian Amazon

Cited by 57 publications

References 29 publications

Epidemiological Characteristic of Malaria Coinfected with Dengue Fever in Hodeidah, Yemen

Epidemiological Characteristic of Malaria Coinfected with Dengue Fever in Hodeidah, Yemen

Concurrent Infection with <b><i>Plasmodium vivax</i></b> and the Dengue and Chikungunya Viruses in a Paediatric Patient from New Delhi, India in 2016

Dengue virus and malaria concurrent infection among febrile subjects within Ilorin metropolis, Nigeria

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