P(RNCH2CH2)N: efficient catalysts for the cyanosilylation of aldehydes and ketones

Organocatalytic synthesis of cyanohydrin trimethylsilyl ethers by potassium 4‐benzylpiperidinedithiocarbamate under solvent‐free conditions

“…It is of particular interest to note that by-products such as those which could be produced by desilylation or benzoin condensation were not observed in all of the reactions studied. [58,59] In the next step, the procedure was further explored by conversion of aliphatic or aromatic ketones into their corresponding cyanohydrin trimethylsilyl ethers (5p-v) in high yields within short reaction time (entries [16][17][18][19][20][21][22]. In general, ketones required longer reaction times compared with aldehydes due to increasing the steric hindrance around the carbonyl functional group.…”

Solvent‐free cyanosilylation of ketones with (CH3)3SiCN (TMSCN) catalyzed by NbF5

“…As shown in Table 2 system requires much less catalyst loading compared with previous studies. 15,16,30,43,44,63 The mechanism of cyanosilylation reaction of ketones catalyzed by NbF 5 is proposed as follows. NbF 5 is hydrolyzed by moisture in the air to give HF.…”

Aluminum phthalocyanine: an active and simple catalyst for cyanosilylation of aldehydes

“…27 Proazaphopsphatrane, a non-ionic strong base, has been reported as a catalyst for aldehydes and ketones. 28 The reaction was carried out with about 3 mol% of catalyst at a reaction time of 1-2 h with yield 89-99%. Lithium chloride acts as an active and simple catalyst for cyanosilylation of aldehydes and ketones.…”