P-R interval in relation to heart rate during exercise and the influence of posture and autonomic tone

Atterhög, Jan-Henrik; Loogna, E.

doi:10.1016/s0022-0736(77)80005-8

Cited by 42 publications

(22 citation statements)

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“…Unlike the regression line described by Atterhog & Loogna (1977) for supine exercise, the regression line during upright treadmill exercise exhibited a highly statistically significant linear relationship in all 36 subjects reported here and I: I I in 10 subjects reported elsewhere (Carruthers & Bailey, 1986), over a wider range of heart rates, i.e. 60 to 160 beats min-' rather than 90 to 140 beats min-1.…”

Section: Resultscontrasting

confidence: 65%

“…The interpolated mean PR intervals at HR of 80, 90 and 100 beats min-1 were 149, 145 and 143 ms respectively for exercise and 140, 134 and 128 ms respectively for isoprenaline infusion and the differences between these paired data for individual subjects were statistically significant. Das et al (1975) and Atterhog & Loogna (1977 Although Cohn & Swift (1924) had recognised the prolongation of PR in children with acute rheumatic fever, it remained for Clarke & Keith (1972) to attempt a systematic evaluation of the possible confounding factor of heart rate. Clarke & Keith (1972) established upper limits for PR interval from resting cardiograms in 672 healthy children and determined that it was appropriate to define upper limits according to age.…”

Section: Resultsmentioning

confidence: 99%

“…The only detailed assessment of HR-PR relationship over a wide range of HR by Atterhog & Loogna (1977). They conducted a series of studies in healthy subjects who exercised in the supine position before and after autonomic blockade with propranolol and atropine.…”

Section: Resultsmentioning

confidence: 99%

“…The range of heart rates was narrow. The studies relied heavily on single or at most a small number of recordings of HR and PR in individual subjects, rather than the wide range of heart rates investigated by Atterhog & Loogna (1977) and ourselves.…”

Section: Resultsmentioning

confidence: 99%

“…Ashman & Hull (1937) reported an inverse HR-PR relationship from resting heart rate observations and established upper limits for PR intervals at given resting HR, but they did not define the association between PR interval and HR within the same individual, nor did their observations include the effects of exercise. More recently, Atterhog & Loogna (1977) studied HR-PR relationships during supine exercise over a broad range of heart rates and described an inverse linear relationship in the HR range of 90 to 140 beats min-'.…”

mentioning

confidence: 99%

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Relationships between heart rate and PR interval during physiological and pharmacological interventions.

Carruthers

McCall

Cordell

et al. 1987

Brit J Clinical Pharma

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1 The relationships between heart rates (HR) and corresponding PR intervals (PR) were studied in 12 healthy young subjects during rest, standing and graduated treadmill exercise to heart rates of 160 to 170 beats min-' and during the infusion of isoprenaline to heart rates of 100 to 110 beats min-'. 4 The exercise model was used to study the indirect (or rate-dependent) effects and the direct actions on atrioventricular conduction of 3-adrenoceptor blocking drugs and calcium channel antagonists, alone and in combination, in three groups of healthy subjects. 5 Control and placebo observations on HR and PR at rest, standing and during exercise in these additional subjects also exhibited individual inverse linear relationships between HR and PR.6 Following the administration of 13-adrenoceptor blockers, PR were prolonged more than expected at the HR observed. Rate-adjusted PR prolongation during exercise exceeded standing which exceeded resting, indicating greater ,B-adrenoceptor blockade in atrioventricular nodal tissue than in sinoatrial nodal tissue at each level of activity.7 ,B-adrenoceptor blocker/calcium antagonist combinations showed variable effects on individual HR-PR relationships, consistent with the known electrophysiological actions of verapamil, nifedipine and diltiazem. Significant prolongation of rate-corrected PR was observed at rest following combinations of verapamil with propranolol, metoprolol and timolol, but not with pindolol. Nifedipine tended to reverse the electrophysiological effects of 13-adrenoceptor blockers, while the effects of diltiazem were intermediate to those of verapamil and nifedipine.Keywords heart rate PR interval linear regression equations exercise isoprenaline 13-adrenoceptor blockers calcium antagonists

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Section: Resultscontrasting

confidence: 65%