p,p′-Methoxyl-diphenyl diselenide-loaded polymeric nanocapsules are chemically stable and do not induce toxicity in mice

Sari, Marcel Henrique Marcondes; Ferreira, Luana Mota; Zborowski, Vanessa Angonesi; Araujo, Paulo Cesar Oliveira; Cervi, Verônica Ferrari; Brüning, César Augusto; Nogueira, Cristina W.

doi:10.1016/j.ejpb.2017.03.018

Cited by 18 publications

(8 citation statements)

References 43 publications

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“…Aligning with our objective of enhancing compound safety through nanotechnology, the treatment with 4-PSCO NC did not exhibit any noticeable alterations in the survival assay in C. elegans . These findings suggest that encapsulating chemical molecules in nanostructures holds promise in mitigating toxic effects, as indicated by previous studies [ 23 , 93 ]. Conversely, when worms were exposed to a higher concentration of 4-PSCO NC, their touch response was reduced compared to that of the control group.…”

Section: Discussionsupporting

confidence: 81%

“…We selected this dose based on previous research that demonstrated the pharmacological effects of organoselenium compounds and coumarin derivatives, encompassing antinociceptive and anti-inflammatory properties [ 4 , 52 ]. The treatment regimen was designed based on previous studies that evaluated the short-term toxicity of the compounds of interest, both in their free and encapsulated forms, as well as the alterations caused by the repeated administration of these compounds [ 23 , 53 , 54 ].…”

Section: Methodsmentioning

confidence: 99%

“…In this regard, nanocarrier systems, particularly polymeric nanostructures, emerge as promising tools for optimizing drug properties with minimal health or environmental repercussions [ 20 , 21 , 22 ]. These systems offer potential solutions to challenges in pharmacokinetics, pharmacodynamics, bioavailability augmentation, and tissue or cellular specificity [ 23 , 24 ]. Therefore, we believe that the combination of organoselenium compounds and nanocarriers constitutes an alternative that has already been explored and demonstrates significant advantages.…”

Section: Introductionmentioning

confidence: 99%

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4-(Phenylselanyl)-2H-chromen-2-one-Loaded Nanocapsule Suspension—A Promising Breakthrough in Pain Management: Comprehensive Molecular Docking, Formulation Design, and Toxicological and Pharmacological Assessments in Mice

da Fonseca,

Prado,

Paltian

et al. 2024

Pharmaceutics

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Therapies for the treatment of pain and inflammation continue to pose a global challenge, emphasizing the significant impact of pain on patients’ quality of life. Therefore, this study aimed to investigate the effects of 4-(Phenylselanyl)-2H-chromen-2-one (4-PSCO) on pain-associated proteins through computational molecular docking tests. A new pharmaceutical formulation based on polymeric nanocapsules was developed and characterized. The potential toxicity of 4-PSCO was assessed using Caenorhabditis elegans and Swiss mice, and its pharmacological actions through acute nociception and inflammation tests were also assessed. Our results demonstrated that 4-PSCO, in its free form, exhibited high affinity for the selected receptors, including p38 MAP kinase, peptidyl arginine deiminase type 4, phosphoinositide 3-kinase, Janus kinase 2, toll-like receptor 4, and nuclear factor-kappa β. Both free and nanoencapsulated 4-PSCO showed no toxicity in nematodes and mice. Parameters related to oxidative stress and plasma markers showed no significant change. Both treatments demonstrated antinociceptive and anti-edematogenic effects in the glutamate and hot plate tests. The nanoencapsulated form exhibited a more prolonged effect, reducing mechanical hypersensitivity in an inflammatory pain model. These findings underscore the promising potential of 4-PSCO as an alternative for the development of more effective and safer drugs for the treatment of pain and inflammation.

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Section: Discussionsupporting

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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4-(Phenylselanyl)-2H-chromen-2-one-Loaded Nanocapsule Suspension—A Promising Breakthrough in Pain Management: Comprehensive Molecular Docking, Formulation Design, and Toxicological and Pharmacological Assessments in Mice

da Fonseca,

Prado,

Paltian

et al. 2024

Pharmaceutics

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“…In this study, inhibition of δ-ALA-D, an increase in aspartate (AST) and alanine aminotransferase (ALT) activities, and a decrease in urea levels were observed, with no effect on creatinine levels, showing that the compound had a hepatotoxic effect but no effect on renal function [56]. A very important finding is that in studies using diselenides-loaded nanocapsules, no toxic effects on mice were shown, which gives hope for a reduction in their harmful properties and possible application in human trials in the future [55,58]. Summarizing the toxicological data of diselenides in in vivo studies, more information from further animal studies on them is needed to unambiguously determine the exact mechanism of their harmful effects on the body, as well as methods to prevent them.…”

Section: Diselenidesmentioning

confidence: 99%

Selenium Compounds as Novel Potential Anticancer Agents

Radomska

Czarnomysy

Radomski

et al. 2021

IJMS

108

113

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The high number of new cancer incidences and the associated mortality continue to be alarming, leading to the search for new therapies that would be more effective and less burdensome for patients. As there is evidence that Se compounds can have chemopreventive activity, studies have begun to establish whether these compounds can also affect already existing cancers. This review aims to discuss the different classes of Se-containing compounds, both organic and inorganic, natural and synthetic, and the mechanisms and molecular targets of their anticancer activity. The chemical classes discussed in this paper include inorganic (selenite, selenate) and organic compounds, such as diselenides, selenides, selenoesters, methylseleninic acid, 1,2-benzisoselenazole-3[2H]-one and selenophene-based derivatives, as well as selenoamino acids and Selol.

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“…In this context, the TBARS content was used, such as a lipid damage marker [ 50 ]. Moreover, NPSH is an important nonenzymatic antioxidant that scavenges reactive oxygen metabolites, such as superoxide (O 2− ) and hydroxyl (OH − ) ions, in the biological system [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Development of Guar Gum Hydrogel Containing Sesamol-Loaded Nanocapsules Designed for Irritant Contact Dermatitis Treatment Induced by Croton Oil Application

et al. 2023

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Irritant contact dermatitis is usually treated with corticosteroids, which cause expressive adverse effects. Sesamol is a phenolic compound with anti-inflammatory and antioxidant properties. This study was designed to evaluate a hydrogel containing sesamol-loaded ethylcellulose nanocapsules for the treatment of irritant contact dermatitis. The nanocapsules presented a size in the nanometric range, a negative zeta potential, a sesamol content close to the theoretical value (1 mg/mL), and a 65% encapsulation efficiency. Nanoencapsulation protected sesamol against UVC-induced degradation and increased the scavenging activity assessed by ABTS and DPPH radicals. The hydrogels were prepared by thickening the nanocapsule suspensions with guar gum (2.5%). The hydrogels maintained the nanometric size of the nanocapsules and a sesamol content of approximately 1 mg/g. The HET-CAM assay classified the hydrogels as nonirritating. The in vitro release of the hydrogel containing sesamol in the nanoencapsulated form demonstrated an initial burst effect followed by a prolonged sesamol release and a lower skin permeation in comparison with the hydrogel containing free sesamol. In addition, it exhibited the best anti-inflammatory effect in the irritant contact dermatitis model induced by croton oil, reducing ear edema and inflammatory cells infiltration, similar to dexamethasone (positive control). Therefore, the hydrogel containing sesamol in the nanoencapsulated form seemed to have a therapeutic potential in treating irritant contact dermatitis.

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p,p′-Methoxyl-diphenyl diselenide-loaded polymeric nanocapsules are chemically stable and do not induce toxicity in mice

Cited by 18 publications

References 43 publications

4-(Phenylselanyl)-2H-chromen-2-one-Loaded Nanocapsule Suspension—A Promising Breakthrough in Pain Management: Comprehensive Molecular Docking, Formulation Design, and Toxicological and Pharmacological Assessments in Mice

4-(Phenylselanyl)-2H-chromen-2-one-Loaded Nanocapsule Suspension—A Promising Breakthrough in Pain Management: Comprehensive Molecular Docking, Formulation Design, and Toxicological and Pharmacological Assessments in Mice

Selenium Compounds as Novel Potential Anticancer Agents

Development of Guar Gum Hydrogel Containing Sesamol-Loaded Nanocapsules Designed for Irritant Contact Dermatitis Treatment Induced by Croton Oil Application

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