p-Menthadienols-rich essential oil from Cymbopogon martini ameliorates skin inflammation

Peppermint as a promising treatment agent in inflammatory conditions: A comprehensive systematic review of literature

“…There were four in vitro (Hejna et al, 2021; Juergens et al, 1998; Kim et al, 2021; Liu et al, 2021) and seven in vivo studies (Abdolmaleki et al, 2013; Atta & Alkofahi, 1998; Bastaki et al, 2018; Ghasemi‐Pirbaluti et al, 2017; Modarresi et al, 2019; Mogosan et al, 2017; Zaia et al, 2016) published between 1998 and 2022. Also, there were three studies that applied both in vitro and in vivo models (Kehili et al, 2020; Singh et al, 2022; Sun et al, 2014).…”

“…In vitro studies that were included in the current systematic review were conducted on lipopolysaccharide (LPS)‐stimulated monocytes from healthy volunteers (Juergens et al, 1998), LPS‐stimulated RAW 264.7 macrophages (Kim et al, 2021; Sun et al, 2014), human epidermal keratinocyte (HaCaT) cells (Kim et al, 2021; Singh et al, 2022), red blood cell (RBC) (Kehili et al, 2020), porcine alveolar macrophages (PAMs) (Hejna et al, 2021), and primary bovine mammary gland epithelial cell (BMECs) (Liu et al, 2021). Also, the dose of peppermint extracts or peppermint essential oils or menthol that was used in these investigations was between 12.5 μg/mL and 100 mg/mL.…”

“…Besides, a recent experimental study by Singh et al (2022) recommended peppermint essential oil as a therapeutic candidate for skin inflammation. In the mentioned study, there was an inhibition of pro‐inflammatory markers in LPS‐stimulated HaCaT cells after treatment with peppermint essential oil (0.001, 0.01, and 0.1% [w/w]) (Singh et al, 2022).…”

“…All in vivo studies that were included in the current systematic review were conducted on rats or mice except one of them that was conducted on rabbits (Singh et al, 2022). Five of them were used single‐dose administration of peppermint or menthol (Abdolmaleki et al, 2013; Atta & Alkofahi, 1998; Mogosan et al, 2017; Singh et al, 2022; Sun et al, 2014). The dose of peppermint extracts or peppermint essential oils or menthol that was used in these investigations was between 20 μL/kg and 800 mg/kg.…”

“…In addition, Liu et al (2021) reported that treatment of BMECs with menthol (10, 50, 100, and 200 mM) caused alleviation of the inflammatory response via the AMP-activated protein kinase/ unc-51 like kinase 1/nuclear factor-E2 associated factor 2 (AMPK/ ULK1/Nrf-2) autophagy pathway. Besides, a recent experimental study by Singh et al (2022) recommended peppermint essential oil as a therapeutic candidate for skin inflammation. In the mentioned study, there was an inhibition of pro-inflammatory markers in LPS-stimulated HaCaT cells after treatment with peppermint essential oil (0.001, 0.01, and 0.1% [w/w]) (Singh et al, 2022).…”