[(p-MeC6H4Pr )2Ru2(SC6H4-p-Bu )3]Cl (diruthenium-1), a dinuclear arene ruthenium compound with very high anticancer activity: An in vitro and in vivo study

Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum

“…Similar findings were obtained earlier when complex 2 was injected intraperitoneally into mice. 26 These findings are important as they suggest that these compounds may be ineffective against cerebral parasitic stages found in cyst-forming coccidia such as Neospora and Toxoplasma.…”

“…These results are in agreement with those previously reported for complex 2 (also known as diruthenium-1 or DiRu-1) which had been intraperitoneally injected into mice. 26…”

“…[21][22][23][24][25] In vivo, one of these complexes, [(Z 6 -p-MeC 6 H 4 Pr i ) 2 Ru 2 (m 2 -SC 6 H 4 -p-Bu t ) 3 ]Cl (2, DiRu-1), prolonged significantly the survival rate of mice experimentally inoculated with tumour cells. 26,27 Some other mononuclear ruthenium complexes were shown to exhibit promising in vitro activities against T. gondii and N. caninum, 28,29 and we have recently reported on the activity of a panel of dinuclear thiolato-bridged arene ruthenium complexes against T. gondii tachyzoites. 30 Some of these compounds efficiently inhibited host cell invasion, and had an IC 50 in the low nanomolar range, low host cell toxicity, and exposure of parasites to these compounds led to distinct alterations in the parasite mitochondrion.…”

Bis(diphenylphosphino)amines-containing ruthenium cymene complexes as potential anti-Mycobacterium tuberculosis agents

“…After 24 h incubation, the medium was removed and 50 μ L resazurin (Sigma-Aldrich, Germany) 0.01% w/v in DMEM, was added to each well and the plates were incubated at 37°C for 3 h. The complexes were synthesized following the route presented in Scheme 1. All complexes were isolated as yellow or orange-yellow solid and were characterized by 31 18(2)°are smaller than those observed for the analogue with dppm,71.29(6)° [50]. Worth noting is the compression in the PeNeP versus PeCeP bond angles of the free ligand compared to the coordinated one.…”

“…The majority of PeNeP-containing ruthenium compounds reported in the literature has an arene, such as p-cymene, benzene or cyclopentadienyl in their structures and is applied in catalytic transfer hydrogenation reactions [25][26][27]. However, it is known that Ru-arene is a promising class of compounds in the biological field with large number of anticancer active examples in the literature [28][29][30][31][32]. Furthermore, one of the most known and promising in this class, RAPTA-C, ruthenium-arene complex containing the phosphine 1,3,5-Triaza-7phosphaadamantane (PTA), is currently on phase I clinical trial for cancer treatment [33].…”