P-glycoprotein suppression by photothermal-responsive nitric oxide releasing nanoplatform for triple-combination therapy of multidrug resistant cancer

Huang, Youyou; Zhang, Jianan; Zhang, Yue; Shi, Ling; Qin, Xiru; Lu, Bing; Ding, Yue; Wang, Yan; Chen, Tingting; Yao, Yong

doi:10.1016/j.matdes.2021.110160

Cited by 19 publications

(14 citation statements)

References 52 publications

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“…Modification by conjugation of HA to the outer surface of the delivery vector improved this delivery system targeting ability, leading to a higher drug concentration at the tumor site, reduced toxicity and side effects of DOX, and an improved curative effect. Huang et al [ 198 ] proposed mesoporous core–shell structured nanocomposites (MCSN) of Cu2-xSe@SiO ( Figure 14 ). It was observed that the composites displayed a concentration-dependent temperature change under laser irradiation.…”

Section: External Stimuli-responsive Drug Delivery Systemsmentioning

confidence: 99%

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Recent Advances in Stimuli-Responsive Doxorubicin Delivery Systems for Liver Cancer Therapy

2022

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Doxorubicin (DOX) is one of the most commonly used drugs in liver cancer. Unfortunately, the traditional chemotherapy with DOX presents many limitations, such as a systematic release of DOX, affecting both tumor tissue and healthy tissue, leading to the apparition of many side effects, multidrug resistance (MDR), and poor water solubility. Furthermore, drug delivery systems’ responsiveness has been intensively studied according to the influence of different internal and external stimuli on the efficiency of therapeutic drugs. In this review, we discuss both internal stimuli-responsive drug-delivery systems, such as redox, pH and temperature variation, and external stimuli-responsive drug-delivery systems, such as the application of magnetic, photo-thermal, and electrical stimuli, for the controlled release of Doxorubicin in liver cancer therapy, along with the future perspectives of these smart delivery systems in liver cancer therapy.

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Section: External Stimuli-responsive Drug Delivery Systemsmentioning

confidence: 99%

“… Schematic illustration of ( a ) the synthetic procedure of MCSN-SNO/DOX and ( b ) the process of photothermal-responsive NO gas release for overcoming multidrug resistant tumor by combination therapy (Reprinted with permission from Ref. [ 198 ]. 2021, Youyou Huang).…”

Section: Figurementioning

confidence: 99%

Recent Advances in Stimuli-Responsive Doxorubicin Delivery Systems for Liver Cancer Therapy

2022

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“…PTT is a minimally invasive and specifically targeted anticancer therapy applying photothermal therapeutic agents (PTA) and NIR laser to kill cancer cells . As a promising strategy for anticancer therapy, PTT has caught much attention in the field of anticancer therapy. − Recent investigations indicate that PTT would overcome MDR by enhancing drug release as well retention and suppressing P-gp expression. , Combined with chemotherapy or CDT, PTT shows a great potential in the reversal of drug resistance in anticancer treatment. − For example, a novel photothermally controlled drug release system (AuNP@mSiO 2 -DOX-FA) was constructed for increasing the drug loading for chemophotothermal therapy of MDR in breast cancer. The gold nanoparticles are triggered by NIR laser to produce hyperthermia effects for DOX release, leading to chemophotothermal therapy for overcoming MDR in cancer …”

Section: Ferroptosis Nanotherapeutics Combined With Other Therapeutic...mentioning

confidence: 99%

“…237−239 Recent investigations indicate that PTT would overcome MDR by enhancing drug release as well retention and suppressing P-gp expression. 240,241 Combined with chemotherapy or CDT, PTT shows a great potential in the reversal of drug resistance in anticancer treatment. 242−245 For example, a novel photothermally controlled drug release system (AuNP@mSiO 2 -DOX-FA) was constructed for increasing the drug loading for chemophotothermal therapy of MDR in breast cancer.…”

Section: Ferroptosis Nanotherapeutics Combinedmentioning

confidence: 99%

Ferroptosis-Driven Nanotherapeutics to Reverse Drug Resistance in Tumor Microenvironment

Zhu

Meng

Wang

et al. 2022

ACS Appl. Bio Mater.

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Ferroptosis, characterized by iron-dependent lipid reactive oxygen species (ROS) accumulation, is non-apoptotic programmed cell death highly relevant to tumor development. It was found to manipulate oncogenes and resistant mutations of cancer cells via lipid metabolism pathways converging on phospholipid glutathione peroxidase (GPX4) that squanders lipid peroxides (L-OOH) to block the iron-mediated reactions of peroxides, thus rendering resistant cancer cells vulnerable to ferroptotic cell death. By accumulating ROS and lipid peroxidation (LPO) products to lethal levels in tumor microenvironment (TME), ferroptosis-driven nanotherapeutics show a superior ability of eradicating aggressive malignancies than traditional therapeutic modalities, especially for the drug-resistant tumors with high metastasis tendency. Moreover, Fenton reaction, inhibition of GPX-4, and exogenous regulation of LPO are three major therapeutic strategies to induce ferroptosis in cancer cells, which were generally applied in ferroptosis-driven nanotherapeutics. In this review, we elaborate current trends of ferroptosisdriven nanotherapeutics to reverse drug resistance of tumors in anticancer fields at the intersection of cancer biology, materials science, and chemistry. Finally, their challenges and perspectives toward feasible translational studies are spotlighted, which would ignite the hope of anti-resistant cancer treatment.

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“…Next, the RSNO was grafted onto mesoporous silica by nitrating the −SH group with tert -butyl nitrite to obtain SCNPs@DMSN-SNO (SMNO) (Figure S4). − The as-prepared g-C 3 N 4 quantum dots (QDs) were uniformly distributed with an average diameter of 2.3 ± 0.4 nm (Figure S5). Ultimately, after the loading of g-C 3 N 4 QDs into mesoporous silica channels and further modification with polyethylene glycol (PEG) molecules to obtain P/SMNO-C (small pore size, P/SMNO-C-S; medium pore size, P/SMNO-C-M; and large pore size, P/SMNO-C-L) (Figures l,m and S6).…”

mentioning

confidence: 99%

Tailoring Silica-Based Nanoscintillators for Peroxynitrite-Potentiated Nitrosative Stress in Postoperative Radiotherapy of Colon Cancer

Liu

Zhang

et al. 2022

Nano Lett.

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The development of a manageable reactive nitrogen species-potentiated nitrosative stress induction system for cancer therapy has remained elusive. Herein, tailored silica-based nanoscintillators were reported for low-dosage X-ray boosting for the in situ formation of highly cytotoxic peroxynitrite (ONOO–). Significantly, cellular nitrosative stress revolving around the intracellular protein tyrosine nitration through ONOO– pathways was explored. High-energy X-rays were directly deposited on silica-based nanoscintillators, forming the concept of an open source and a reduced expenditure-aggravated DNA damage strategy. Moreover, the resultant ONOO–, along with the released nitric oxide, not only can act as “oxygen suppliers” to combat tumor hypoxia but also can induce mitochondrial damage to initiate caspase-mediated apoptosis, further improving the therapeutic efficacy of radiotherapy. Thus, the design of advanced nanoscintillators with specific enhanced nitrosative stress offers promising potential for postoperative radiotherapy of colon cancer.

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P-glycoprotein suppression by photothermal-responsive nitric oxide releasing nanoplatform for triple-combination therapy of multidrug resistant cancer

Cited by 19 publications

References 52 publications

Recent Advances in Stimuli-Responsive Doxorubicin Delivery Systems for Liver Cancer Therapy

Recent Advances in Stimuli-Responsive Doxorubicin Delivery Systems for Liver Cancer Therapy

Ferroptosis-Driven Nanotherapeutics to Reverse Drug Resistance in Tumor Microenvironment

Tailoring Silica-Based Nanoscintillators for Peroxynitrite-Potentiated Nitrosative Stress in Postoperative Radiotherapy of Colon Cancer

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