p-Coumaric acid inhibits the Listeria monocytogenes RecA protein functions and SOS response: An antimicrobial target

Ojha, Debika; Patil, K. Neelakanteshwar

doi:10.1016/j.bbrc.2019.07.093

Cited by 35 publications

(12 citation statements)

References 31 publications

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“…Few inhibitors of DNA repair have been verified so far. For example, p -coumaric acid was found to interfere with the DNA-binding ability of RecA in Listeria monocytogenes and increased the activity of ciprofloxacin against this pathogen . Another study found that zinc inhibits the ability of RecA to bind to single-stranded DNA, suggesting a potential application for zinc ionophores .…”

Section: Part 2: Antibiotic Combinationsmentioning

confidence: 99%

“…For example, p-coumaric acid was found to interfere with the DNA-binding ability of RecA in Listeria monocytogenes and increased the activity of ciprofloxacin against this pathogen. 213 Another study found that zinc inhibits the ability of RecA to bind to single-stranded DNA, suggesting a potential application for zinc ionophores. 214 However, the effectivity and cytotoxicity of zinc ionophores would depend on the external zinc concentration, 215 which may limit this approach to topical applications or targeted drug delivery and release approaches.…”

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confidence: 99%

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Multitarget Approaches against Multiresistant Superbugs

2020

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Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for drug discovery to keep pace. Often, resistance against a new drug develops even before it reaches the market. This continued resistance crisis has demonstrated that resistance to antibiotics with single protein targets develops too rapidly to be sustainable. Most successful long-established antibiotics target more than one molecule or possess targets, which are encoded by multiple genes. This realization has motivated a change in antibiotic development toward drug candidates with multiple targets. Some mechanisms of action presuppose multiple targets or at least multiple effects, such as targeting the cytoplasmic membrane or the carrier molecule bactoprenol phosphate and are therefore particularly promising. Moreover, combination therapy approaches are being developed to break antibiotic resistance or to sensitize bacteria to antibiotic action. In this Review, we provide an overview of antibacterial multitarget approaches and the mechanisms behind them.

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Section: Part 2: Antibiotic Combinationsmentioning

confidence: 99%

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confidence: 99%

Multitarget Approaches against Multiresistant Superbugs

2020

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“…The decreasing rank based on the summed total content of the determined phenolic compounds was PEA (244·0 ± 11·6 mg 100 g −1 )>PEM (157·3 ± 18·8 mg g −1 )>PEC (93·0 ± 0·7 mg 100 g −1 ). Previous studies have reported antibacterial effects of catechin (Sinsinwar and Vadivel 2020), p ‐coumaric acid (Bag and Chattopadhyay 2017; Ojha and Patil 2019) and procyanidin B 2 (Alejo‐Armijo et al . 2017) on some pathogenic bacteria.…”

Section: Resultsmentioning

confidence: 99%

Phenolic-rich extracts from acerola, cashew apple and mango by-products cause diverse inhibitory effects and cell damages on enterotoxigenic Escherichia coli

Lima

Magnani

Lima

et al. 2022

Letters in Applied Microbiology

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Significance and Impact of the Study: Enterotoxigenic Escherichia coli (ETEC) is one of the main causes of diarrhoea in humans and animals. The increasing resistance of ETEC strains to clinically relevant antibiotics has prompt the necessity to search for novel substances with inhibitory efficacy. This is the first study showing the capability of phenolic-rich extracts of acerola and cashew apple by-products causing the inhibition of distinct ETEC strains, with disturbance of various physiological functions, indicating these substances as potential antimicrobials to be exploited in solutions to control ETEC in humans and animals.

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“…It can be approached from the following five aspects: (1) Block bacterial SOS response pathway; (2) Interrupt SOS-to-prophage activation signal; (3) Reduce bacterial inflammatory properties or relieve intestinal inflammation with external intervention; (4) Vaccination against gut disease; (5) Avoid the abuse of antibiotics ( Figure 2C ). In recent years, the short first in class α-helical peptide, phenolic compound N-acetylcysteine, 5-amino-1-(carbamoylmethyl)-1H-1, 2, 3-triazole-4-carboxamide scaffold, zinc, phthalocyanine tetrasulfonic acid, fermentates from probiotic strains, and p-Coumaric acid were found to inhibit RecA protein activities, thereby blocking the SOS system ( Alam et al, 2016 ; Bunnell et al, 2017 ; Yakimov et al, 2017 ; Selwood et al, 2018 ; Ojha and Patil, 2019 ; Prazdnova et al, 2019 ; Rodríguez-Rosado et al, 2019 ). RecA protein inhibitor bind to the L2 loop through the ssDNA site on the epithelium ( Bellio et al, 2017 ).…”

Section: Effects Of Prophage Activation On Physiological Characteristics Of Bacteria and Intestinal Healthmentioning

confidence: 99%

Prophage Activation in the Intestine: Insights Into Functions and Possible Applications

Wang

et al. 2021

Front. Microbiol.

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Prophage activation in intestinal environments has been frequently reported to affect host adaptability, pathogen virulence, gut bacterial community composition, and intestinal health. Prophage activation is mostly caused by various stimulators, such as diet, antibiotics, some bacterial metabolites, gastrointestinal transit, inflammatory environment, oxidative stress, and quorum sensing. Moreover, with advancements in biotechnology and the deepening cognition of prophages, prophage activation regulation therapy is currently applied to the treatment of some bacterial intestinal diseases such as Shiga toxin-producing Escherichia coli infection. This review aims to make headway on prophage induction in the intestine, in order to make a better understanding of dynamic changes of prophages, effects of prophage activation on physiological characteristics of bacteria and intestinal health, and subsequently provide guidance on prophage activation regulation therapy.

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p-Coumaric acid inhibits the Listeria monocytogenes RecA protein functions and SOS response: An antimicrobial target

Cited by 35 publications

References 31 publications

Multitarget Approaches against Multiresistant Superbugs

Multitarget Approaches against Multiresistant Superbugs

Phenolic-rich extracts from acerola, cashew apple and mango by-products cause diverse inhibitory effects and cell damages on enterotoxigenic Escherichia coli

Prophage Activation in the Intestine: Insights Into Functions and Possible Applications

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