P‐cadherin expression in breast carcinoma indicates poor survival

Soler, Aléjandro Peralta; Knudsen, Karen A.; Salazar, Hernando; Han, Aaron C.; Keshgegian, Albert A.

doi:10.1002/(sici)1097-0142(19991001)86:7<1263::aid-cncr23>3.3.co;2-u

Cited by 46 publications

(71 citation statements)

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“…The present study shows that P-cadherin expression is strongly associated with high histological grade of DCIS and with loss of ER, as already reported by two other studies in invasive ductal carcinoma [25,27]. Moreover, almost all P-cadherin-positive cases were also positive to c-erbB-2, and some have presented p53 immunoreactivity.…”

Section: Discussionsupporting

confidence: 90%

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P-cadherin expression is associated with high-grade ductal carcinoma in situ of the breast

et al. 2002

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Cadherins are calcium-dependent cell-cell adhesion glycoproteins, separated into several subclasses with distinct adhesive specificities and tissue distribution, which play an important role in many cellular events. We analyse the expression of E-, N- and P-cadherin in a series of ductal carcinoma in situ (DCIS) of the breast, since this disease represents a heterogeneous group, with different risks of progression to invasive breast carcinoma. We also studied the correlation between cadherin expression and DCIS classification systems, namely the Van Nuys and the Holland et al. classification, this latter based on cytonuclear differentiation and cell polarity. Our results showed that, regardless the classification applied, P-cadherin expression is strongly associated with high histological grade of DCIS (P=0.0047) and lack of estrogen receptors (P=0.0008). The use of Holland et al. classification showed a significant correlation between P-cadherin expression and decreased cell polarity (P=0.01). In conclusion, P-cadherin expression seems to be more relevant in DCIS pathogenesis than the altered expression of any other cadherin, including the decrease of E-cadherin expression.

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Section: Discussionsupporting

confidence: 90%

“…P-cadherin, however, can be expressed in a subset of breast cancers [25,28]. Recently, Peralta Soler et al observed P-cadherin expression in invasive ductal carcinomas with higher histological grade and poor survival, suggesting that this protein could constitute a prognostic marker [27].…”

Section: Introductionmentioning

confidence: 99%

P-cadherin expression is associated with high-grade ductal carcinoma in situ of the breast

et al. 2002

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“…In this model, expression of P-cadherin is associated with poor survival and constitutes an independent prognostic indicator [34]; it is also associated with an infiltrative growth pattern [34]. This may argue in favour of a role for P-cadherin in the acquisition of more aggressive behaviour in breast tumours.…”

Section: Discussionmentioning

confidence: 89%

“…Recent publications on the expression of P-cadherin and breast cancer [25,34] showed an important role for this molecule in breast carcinogenesis. In this model, expression of P-cadherin is associated with poor survival and constitutes an independent prognostic indicator [34]; it is also associated with an infiltrative growth pattern [34].…”

Section: Discussionmentioning

confidence: 99%

Mucoepidermoid carcinoma of the thyroid: a tumour histotype characterised by P-cadherin neoexpression and marked abnormalities of E-cadherin/catenins complex

et al. 2002

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The cadherin/catenins complex regulates cell-cell adhesion and motility and is believed to have an invasion suppressor role. Primary mucoepidermoid carcinoma of the thyroid (MECT) is a rare tumour characterised by a distinct morphological appearance and a questionable histogenesis. The coexistence of papillary thyroid carcinoma (PTC) foci in many patients with MECT suggests an association between the two tumour histotypes. In an attempt to clarify the putative relationship between MECT and PTC, we analysed tissue from 11 patients with MECT by immunohistochemistry (E-, P- and N-cadherins and alpha-, beta- and gamma-catenins). The E-cadherin gene was also analysed by polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP). The results were compared with a control group of normal thyroid, classical PTC and the diffuse sclerosing variant of PTC. Compared with normal thyroid and PTC, MECT displays marked abnormalities of the cadherin/catenin complex. Such abnormalities include the consistent neoexpression of P-cadherin and major alterations in the expression of E-cadherin and the three catenins. Our results point to the close relationship between the de novo expression of P-cadherin and the disruption of the cadherin/catenins complex with the squamoid phenotype of MECT.

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“…For example, over expression of N-cadherin in E-cadherin-expressing breast cancer cells caused an increase in their invasive and metastatic potential [6], despite the vital role of E-cadherin in suppression of invasion and metastasis [2][3][4]9]. There is conflicting evidence regarding the role of P-cadherin in carcinogenesis with increased P-cadherin expression associated with poor survival in breast and ovarian cancer [10][11][12] or with better survival [13].…”

Section: Introductionmentioning

confidence: 99%

The cadherin switch in ovarian high-grade serous carcinoma is associated with disease progression

et al. 2011

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Ovarian high-grade serous carcinoma (HGSC) often has a poor prognosis because of late presentation, lack of sensitivity and specificity of screening modalities and the development of chemoresistance. New targeted therapy is required if survival in these cases is to improve. The profile of E-, P- and N-cadherins in ovarian cancer and its association with survival remain poorly understood. Reduced expression of E-cadherin in prostate cancer associated with increase in the expression of N- and P-cadherins is described as cadherin switch. We hypothesised that there is a switch in the expression of cadherins that regulates the behaviour of HGSC and possibly its outcome. To identify the stages of the cadherin switch in HGSC, we studied the immunoexpression of E-, P- and N-cadherins in a cohort of 177 cases of HGSC. High expression of P-cadherin was associated with poor patient survival and was significantly higher in stage 2 disease when compared with stage 1 and stage 3 disease (P = 0.033). In contrast, loss of E-cadherin was observed in stage 3 HGSC when compared with other stages (P = 0.050). E-, P- and N- cadherin expressions were significantly associated with disease outcome when assessed individually and in various combinations with an interesting profile. Our results indicate that the cadherin switch alters through progression of HGSC. The profile of combined cadherin expressions in association with survival raises expectations in targeted therapy.

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P‐cadherin expression in breast carcinoma indicates poor survival

Cited by 46 publications

References 0 publications

P-cadherin expression is associated with high-grade ductal carcinoma in situ of the breast

P-cadherin expression is associated with high-grade ductal carcinoma in situ of the breast

Mucoepidermoid carcinoma of the thyroid: a tumour histotype characterised by P-cadherin neoexpression and marked abnormalities of E-cadherin/catenins complex

The cadherin switch in ovarian high-grade serous carcinoma is associated with disease progression

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