Background and Aim: The hepatit is one of the most common and serious elements of hepatitis in the world. The cause of the infection is unknown but previous findings indicate that disturbance in function of immune system, B lymphocyte, Foxp3, CD4 + and CD8 + are the probability causes. The candida species are the natural mouth florae in very people and exist in the mouth of the carrier people in lower concentration about 200-500 cells in one milliliter of saliva. The goal of this search was to comparison the level of oral Candida albicans in healthy and HBsAg + persons referred to Ahwaz Transmittal Blood Organization in 2008.