P. acnes-Driven Disease Pathology: Current Knowledge and Future Directions

Leheste, Joerg R.; Ruvolo, Kathryn E.; Chrostowski, Joanna E.; Rivera, Kristin; C, Husko; Miceli, Alyssa; Selig, Martin K.; Brüggemann, Holger; Torres, Germán

doi:10.3389/fcimb.2017.00081

Cited by 42 publications

(32 citation statements)

References 84 publications

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“…The Gram‐positive, anaerobic, slow‐growing bacterium Cutibacterium acnes (formerly Propionibacterium acnes ) is responsible for recrudescent or chronic acne, and can also affect implants, such as cardiovascular devices and prosthetic joints (Achermann, Goldstein, Coenye, & Shirtliff, 2014; Lee, Byun, & Kim, 2019). More than 50% of C. acnes isolates are resistant to topical macrolides, making treatment challenging (Leheste et al, 2017; Portillo, Corvec, Borens, & Trampuz, 2013; Van Boeckel et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Caenorhabditis elegansmounts a p38MAPKpathway‐mediated defence toCutibacterium acnesinfection

Huang

Pan

Kim

et al. 2020

Cellular Microbiology

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Cutibacterium acnes is capable of inducing inflammation in acne and can lead to a chronic prostatic infection. The diverse pathogenicity among different strains of C. acnes has been presented, but simple appropriate animal models for the evaluation of this bacterium are lacking. In this study, the nematode Caenorhabditis elegans was used as an invertebrate infection model. We revealed that C. acnes type strain ATCC 6919 caused lethal infections to C. elegans in solid and liquid culture media (p < .0001). Compared with the strain ATCC 6919, the antibiotic‐resistant strain HM‐513 was more virulent, resulting in reduced survival (p < .0001). Four different C. acnes strains killed worms with a p value of less than .0001 when provided to C. elegans at 4.8 × 108 CFU/ml. The infection model was also employed to explore host defence responses. An increase in numerous immune effectors in response to C. acnes was detected. We focused on nine C‐type lectins, including: clec‐13, clec‐17, clec‐47, clec‐52, clec‐60, clec‐61, clec‐70, clec‐71 and clec‐227. The induced expression of these C‐type lectin genes was down‐regulated in mutant worms deficient in the p38 mitogen‐activated protein kinase (MAPK) pathway. Meanwhile, PMK‐1 (MAPK) was phosphorylated and activated at the onset of C. acnes infection. By monitoring the survival of mutant worms, we found that PMK‐1, SEK‐1 (MAPKK) and TIR‐1 (MAPKKK) were critical in responding to C. acnes infection. C. elegans pmk‐1 and tir‐1 mutants exhibited higher mortality to C. acnes infection (p < .0001). In conclusion, C. elegans serves as a simple and valuable model to study C. acnes virulence and facilitates improvements in understanding of host innate immune responses.

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Section: Introductionmentioning

confidence: 99%

Caenorhabditis elegansmounts a p38MAPKpathway‐mediated defence toCutibacterium acnesinfection

Huang

Pan

Kim

et al. 2020

Cellular Microbiology

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“…P. acnes is a part of commensal microbiota and is generally present in human skin, hair follicles, and mucous membranes [5,18]. It is well known for its involvement in the pathogenesis of acne vulgaris [19]; moreover, its role in various postoperative infections such as endocarditis, endophthalmitis, and central nervous system (CNS) infections has been reported [5].…”

Section: Discussionmentioning

confidence: 99%

“…acnes is a part of commensal microbiota and is generally present in human skin, hair follicles, and mucous membranes [5,18]. It is well known for its involvement in the pathogenesis of acne vulgaris [19]; moreover, its role in various postoperative infections such as endocarditis, endophthalmitis, and central nervous system (CNS) infections has been reported [5]. In addition, P. acnes can invade and persist in epithelial cells and circulating macrophages in its intracellular latent form [5], which results in chronic inflammation such as sarcoidosis [6,20,21].…”

Section: Discussionmentioning

confidence: 99%

“…P. acnes is a slow-growing, non-spore forming anaerobic gram-positive bacillus that ubiquitously resides in human skin and hair follicles [5]. Intriguingly, P. acnes can invade and persist in epithelial cells and circulating macrophages, thus inducing chronic inflammation [5]; it is considered the most implicated etiological agent for sarcoidosis in Japan because it has been isolated by bacterial culture from systemic sarcoidosis lesions at high ratios [6].…”

Section: Introductionmentioning

confidence: 99%

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Propionibacterium acnes-associated chronic hypertrophic pachymeningitis followed by refractory otitis media: a case report

et al. 2020

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Background: Hypertrophic pachymeningitis (HP) is a rare disorder that involves localized or diffuse thickening of the dura mater. HP is associated with various inflammatory, infectious, and malignant diseases, such as rheumatic arthritis, sarcoidosis, anti-neutrophil cytoplasmic antibody-associated vasculitis, IgG4-related disorders, syphilis, tuberculosis, bacterial and fungal infections, cancer, and idiopathic diseases, when evaluation fails to reveal a cause. Among them, chronic infection with Propionibacterium acnes is a rare etiology of HP, and its pathology remains unclear. Case presentation: An 80-year-old man having refractory otitis media with effusion of the right ear presented with progressive right-sided headache and nausea. Post-contrast brain magnetic resonance imaging revealed right mastoiditis and remarkable thickening of the dura mater and enhancement of pia mater extending from the right middle cranial fossa to the temporal lobe. HP secondary to middle ear infection was suspected, and a biopsy of the right mastoid was performed. An anaerobic culture of the biopsied right mastoid showed the growth of P. acnes, and histopathological examination using P. acnes-specific monoclonal antibody (PAB antibody) revealed the infiltration of inflammatory cells with P. acnes. Moreover, using PAB antibody, P. acnes was detected in the biopsy specimen of the thickening dura mater. No granulomas were identified in either specimen. HP was resolved with long-term administration of antibiotics and steroids. Conclusion: This is the first documentation of pathologically demonstrated chronic HP associated with P. acnes infection followed by refractory otitis media. This report showed that chronic latent P. acnes infection induces chronic inflammation.

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“…In addition, Propionibacterium acnes ( P . acnes ), a skin bacterium closely associated with acne, is reported to be associated with prostatic inflammation and carcinogenesis [ 7 – 9 ]. Several observational studies have found a possible link between a history of acne and prostate cancer risk but with inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

Is acne in adolescence associated with prostate cancer risk? Evidence from a meta-analysis

et al. 2018

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IntroductionPrevious studies regarding the relationship between acne and prostate cancer risk have reported inconsistent results. We performed the present meta-analysis of observational studies to summarize the evidence on this association.MethodsA comprehensive literature search up to March 2018 was performed in PubMed, Scopus, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) databases. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were estimated with a random effects model. The Q statistic and the I2 index were used to evaluate the heterogeneity across the studies.ResultsEight studies were ultimately included in this meta-analysis. In the overall analysis, no significant association was found between acne and prostate cancer risk (OR = 1.08, 95% CI 0.93–1.25). A significant heterogeneity was observed across studies (P = 0.006, I2 = 64.5%). In the subgroup analysis by study design, a significant association was observed in the cohort studies (OR = 1.51, 95% CI 1.19–1.93) but not in the case-control studies (OR = 0.98, 95% CI 0.86–1.12).ConclusionsIn summary, this meta-analysis did not find an association between acne in adolescence and prostate cancer risk. However, because there was some heterogeneity in the overall analysis and a significant association was observed in the meta-analysis of the cohort studies, further well-designed large prospective studies are warranted to confirm our results.

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P. acnes-Driven Disease Pathology: Current Knowledge and Future Directions

Cited by 42 publications

References 84 publications

Caenorhabditis elegansmounts a p38MAPKpathway‐mediated defence toCutibacterium acnesinfection

Caenorhabditis elegansmounts a p38MAPKpathway‐mediated defence toCutibacterium acnesinfection

Propionibacterium acnes-associated chronic hypertrophic pachymeningitis followed by refractory otitis media: a case report

Is acne in adolescence associated with prostate cancer risk? Evidence from a meta-analysis

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