P.98 What is the optimum ω-3 to ω-6 fatty acid (FA) ratioof parenteral lipid emulsions in postoperative trauma?

Morlion, Bart; Torwesten, E.; Wrenger, Katja; Puchstein, C; Fürst, Peter

doi:10.1016/s0261-5614(97)80222-1

Cited by 35 publications

(24 citation statements)

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“…The reduced content of ˆ6 fatty acids and the increased amount of monounsaturated and 3 fatty acids are in accordance with current National Institutes of Health (NIH) recommendations [19,20]. The ˆ6/ˆ3 fatty acid ratio in SMOF is approximately 2:1, which is proposed to be the optimum ratio for parenteral lipid emulsions [11,20].…”

Section: Introductionsupporting

confidence: 75%

“…Olive oil, rich in monounsatured fatty acids, shows benefits regarding immune function and lipid peroxidation [2,[6][7][8][9][10]. The inclusion of fish oil-derived ˆ3 fatty acids decreases the ˆ6/ˆ3 fatty acid ratio and therefore has the potential to better maintain the fatty acid balance in membrane phospholipids and to exert important modulations of eicosanoid and cytokine biology [11][12][13][14][15]. Consequently, the new emulsion may have protective effects in states of hyperinflammation and immunosuppression which are often found in postoperative and critically ill patients.…”

Section: Introductionmentioning

confidence: 99%

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Elimination and Tolerance of a New Parenteral Lipid Emulsion (SMOF) – A Double-Blind Cross-Over Study in Healthy Male Volunteers

Schlotzer

Kanning

2004

Ann Nutr Metab

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Aims: The objective of this phase I study was to investigate plasma elimination and tolerance of a new lipid emulsion based on soybean oil, medium chain triglycerides (MCT), olive oil and fish oil (SMOF). Methods: In a double-blind, randomized, cross-over study, 12 healthy male subjects received SMOF 20% and a standard soybean oil emulsion (Lipovenoes^® 20%, both Fresenius Kabi). Lipid emulsions were infused at a rate of 0.125 g fat/kg body weight/h over 6 h. Before, during and up to 24 h after infusion, lipid metabolism parameters and numerous clinical, chemical and hematological parameters, vital signs and local tolerance were determined. Results: Infusion of SMOF induced a less marked increase of serum triglyceride concentration. At the end of infusion, mean serum triglyceride concentration was significantly lower with SMOF (p < 0.05). Triglyceride half-life was significantly shorter for SMOF than for Lipovenoes (p < 0.001). Infusion of SMOF was apparently associated with higher glycerol concentration (NS). Routine laboratory parameters, vital signs and local tolerance showed no evidence of infusion-related abnormalities. Conclusion: SMOF was eliminated significantly faster than the standard lipid emulsion. This is of potential benefit in patients with limited triglyceride elimination capacity. The safety evaluation revealed a good systemic and local tolerance of SMOF.

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Section: Introductionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Elimination and Tolerance of a New Parenteral Lipid Emulsion (SMOF) – A Double-Blind Cross-Over Study in Healthy Male Volunteers

Schlotzer

Kanning

2004

Ann Nutr Metab

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“…This model provides a superior opportunity to study innovative treatment by standard processes. In addition, bacteriologic data about experimental pancreatitis are available for this model [16,17] . ANP in small animals is 4-6 times faster than in humans and most patients with acute pancreatitis are admitted 24-36 h after the onset of pancreatitis [22] .…”

Section: Discussionmentioning

confidence: 99%

“…The second group (sham + 3FA, n = 15) was treated in the same way as the first group, but lipid solution was infused 0.8 ml/ kg/h (1.8 g soybean/kg + 0.2 g fish oil/kg, total 2 g/kg) and 5.2 ml/ kg/h saline for the last 42 h [17] . Fresenius Kabi (Istanbul, Turkey) provided the lipid solution which contained 10% fish oil and 90% soybean oil.…”

Section: Experimental Protocolmentioning

confidence: 99%

Effects of ω–3 Fatty Acids on Acute Necrotizing Pancreatitis in Rats

Alhan¹,

Türkyılmaz²,

Erçín

et al. 2006

Eur Surg Res

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The aim of this study was to investigate the influence ofω–3 fatty acids (ω3FA) on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. The induction of ANP resulted in significant increases in mortality rate, intestinal permeability, bacterial infection in pancreas and extrapancreatic organs, and serum activity of urea and amylase, alanine transferase (ALT), interleukin (IL)-6, tumor necrotizing factor-α (TNF-α), lactate dehydrogenase (LDH) in bronchoalveolar lavage (BAL) fluid, tissue activity of myeloperoxidase (MPO) and malondialdehyde (MDA) in the pancreas and lung, and a considerable decrease of concentrations of calcium, protein and albumin. The use of ω3FA reduced mortality, phenol sulfophthalein excretion in urine, bacterial infection in pancreas, liver, spleen, MPO and MDA levels in pancreatic and lung tissue, LDH level in BAL fluid and serum IL-6 and TNF-α values. Serum triglyceride increased only in the ω3FA groups. Serum amylase, ALT, calcium, urea, protein, IL-1, and degree of pancreatic damage indicated no difference between the pancreatitis groups. Increased intestinal permeability and cytokine levels, and free radical damage play an important role during the course of acute pancreatitis. The treatment with ω3FA improves these effects. ω3FA may be useful in the treatment during ANP in rats. Therefore, it can be beneficial in patients with pancreatitis.

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“…According to the recommendations of the Institute of Nutrition of the Russian Academy of Medical Sciences, Russia, the ratio of ω-3:ω-6 polyunsaturated fatty acids in the diet of a healthy person should be 1:10, and in the medical diet, it should be range from 1:3 to 1:5 [8]. Based on the majority of clinical and experimental studies, the ratio of ω-3 and ω-6 in the human diet is recommended to be from 1:4 to 1:2 [3,4,9]. The British Nutrition Foundation maintains that the ideal ratio between the families of ω-3 and ω-6 PUFAs should be 1:6 [4].…”

Section: Literature Review and Problem Statementmentioning

confidence: 99%

New vegetable oil blends to ensure high biological value and oxidative stability

Nosenko

Shemanska

Bakhmach

et al. 2017

EEJET

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P.98 What is the optimum ω-3 to ω-6 fatty acid (FA) ratioof parenteral lipid emulsions in postoperative trauma?

Cited by 35 publications

References 0 publications

Elimination and Tolerance of a New Parenteral Lipid Emulsion (SMOF) – A Double-Blind Cross-Over Study in Healthy Male Volunteers

Elimination and Tolerance of a New Parenteral Lipid Emulsion (SMOF) – A Double-Blind Cross-Over Study in Healthy Male Volunteers

Effects of ω–3 Fatty Acids on Acute Necrotizing Pancreatitis in Rats

New vegetable oil blends to ensure high biological value and oxidative stability

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