P-603 Phase I results of RTOG L-0117; a phase i/II dose intensificationstudy using 3DCRT and concurrent chemotherapy for patients with inoperable NSCLC

Bradley, J. Andrew; Graham, Mary V.; Swann, S.; Byhardt, R.; Govindan, Ramaswamy; Fowler, Jack; Purdy, James A.; Michalski, J.; Gore, E.; Choy, Hak

doi:10.1016/s0169-5002(05)81096-7

Cited by 2 publications

(2 citation statements)

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“…This means that the CTV in our plans should receive at least 57 Gy but not more than 64.2 Gy. The dose tolerance limits for organs at risk (OAR) were taken from RTOG protocol 0117 [48] for IMRT treatment of lung cancer. In this protocol the maximum heart dose is 40 Gy, maximum spinal cord dose 45 Gy and the lungs must have V20 ≤ 30% .…”

Section: Dose Prescription and Oar Dose Tolerancementioning

confidence: 99%

A Robust 4D Treatment Planning Approach For Lung Radiotherapy

Pokhrel¹

2021

Preprint

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4D treatment plans are optimized to compensates for a patient's individual respiratory motion. However, changes in the time spent in the each respiratory state may render a 4D plan invalid. We introduced and evaluate two robust treatment planning approaches to compensate for respiratory motion variations. Robust 4D plans can be designed either using an average pdf approach or a worst case pdf approach. We tested these approaches on two motion variation scenarios and compared them with nominal 4D optimization and ITV plans. The nominal 4D plans were very sensitive to the variation in respiration pattern while the average pdf and worst case pdf plans were less sensitive under the similar variations. The average and worst case pdf plans were not as robust as the ITV plans but had better healthy tissue sparing. The worst case pdf approach was found to be the most promising for robust 4D plan optimization.

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Section: Dose Prescription and Oar Dose Tolerancementioning

confidence: 99%