P-54 BISQUIT: A randomized phase II study of the administration of prebiotics and probiotics during definitive treatment with chemotherapy-radiotherapy for patients with squamous cell carcinoma of the anal canal

Abstract

Conclusion: Thus, the use of surgical removal of metastases in the liver with CRC, at one of the stages of treatment, significantly increases its effectiveness, with both solitary and multiple metastatic liver damage compared with only conservative methods.

Oral Administration of Probiotics Reduces Chemotherapy-Induced Diarrhea and Oral Mucositis: A Systematic Review and Meta-Analysis

“…Following the above inclusion and exclusion criteria, 507 articles (ongoing studies, unexpectedly terminated trials, noncancer patients, not oral probiotic use, in vitro studies, nonchemotherapy studies, and reviews) and 38 duplicate articles were removed after carefully reading their titles and abstract, leaving only 51 articles. After reading the remaining articles, 39 additional studies were further excluded because of that 12 studies did not include cancer patients or they were not receiving chemotherapy (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37), two did not include oral probiotic use (38,39), 20 had no record of diarrhea or oral mucositis in patients (40-59) (18 of them did not include diarrhea or oral mucositis indicators (40)(41)(42)(43)(44)(45)(46)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59), and the other two studies only recorded the frequency of diarrhea or oral mucositis rather than the number of patients who had the adverse reactions (47, 48)), and five were not randomized controlled trials (60)(61)(62)(63)(64). Finally, 12 articles were selected for the meta-analysis.…”

The gut dysbiosis-cancer axis: illuminating novel insights and implications for clinical practice

“…One of the study on gastric cancer patients reported that fiber-enriched nutrition formula, and fiberand probioticenriched nutrition formula led to shorter hospitalization period with a minimized diarrhea symptoms (Charteris, 2017). Another study on patients with localized anal canal squamous cell cancer was performed to demonstrate the effect of the gut microbiota and prebiotics during radiotherapy for the effectiveness of treatment and clinical outcomes (Riechelmann et al, 2020). The abundance of Bifidobacterium and Enterococcus was increased and with a decrease in the prevalence of Bacteroides levels owing to the intake of prebiotic during the preoperative period, while as in the postoperative period, the prevalence of Enterococcus, Bacillus, Lactococcus, and Streptococcus raised in the non-prebiotic group.…”

“…Perhaps, the occurrence of beneficial strains of Escherichia and Shigella enhanced after prebiotic Frontiers in Pharmacology frontiersin.org consumption in the postoperative period. Moreover, prebiotic consumption had significant impact on immunologic indices during the preoperative and postoperative therapy stages (Riechelmann et al, 2020). Significant increase of immunoglobulin (Ig)G, IgM, and transferrin was observed during the preoperative period, and IgG, IgA, suppressor/ cytotoxic T cells (CD3 + CD8 + ), and total B lymphocytes levels in the postoperative period was raised, compared to nonprebiotic group (Riechelmann et al, 2020).…”

“…Moreover, prebiotic consumption had significant impact on immunologic indices during the preoperative and postoperative therapy stages (Riechelmann et al, 2020). Significant increase of immunoglobulin (Ig)G, IgM, and transferrin was observed during the preoperative period, and IgG, IgA, suppressor/ cytotoxic T cells (CD3 + CD8 + ), and total B lymphocytes levels in the postoperative period was raised, compared to nonprebiotic group (Riechelmann et al, 2020). In a study on 74 French patients, Ruault et al demonstrated alteration in biological markers, prior and post 3 months daily consumption of fructo-oligosaccharide.…”