P.484 Epidemiological characterization of chronic hepatitis C in Portugal

Areias, Jorge; Gomes, Harrison Magdinier; Mocho, Maria Luísa; Matos, Ludmilla; Valente, Cristina; Vale, A. M. H.

doi:10.1016/s1386-6532(06)80657-8

Cited by 4 publications

(6 citation statements)

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“…Blood transfusions (15.2%), surgery (22.2%) and sexual contacts (18.9%) were also suggested as major risk factors. A large proportion of cases has unidentified risk factors (14.1%) in this analysis (242).…”

Section: Resultsmentioning

confidence: 88%

“…Three reports are available describing the genotype distribution in Portugal (242, 245, 246). Areias et al provide the most robust and representative sample available; however, no subgenotyping of HCV infection was carried out.…”

Section: Resultsmentioning

confidence: 99%

“…Genotype 1 was the most prevalent genotype (52.2%), followed by genotype 3 (34.0%). Genotype 4 was recorded in 7% and genotype 2 was seen at the smaller proportion of 2.4% (242). Smaller studies also suggest that genotype 1 is the most prevalent genotype (71.4 and 59.3% respectively) (245,246).…”

Section: Genotypementioning

confidence: 99%

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A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel

Cornberg

Razavi

Alberti

et al. 2011

Liver International

369

294

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Background and Aim: Decisions on public health issues are dependent on reliable epidemiological data. A comprehensive review of the literature was used to gather country-specific data on risk factors, prevalence, number of diagnosed individuals and genotype distribution of the hepatitis C virus (HCV) infection in selected European countries, Canada and Israel. Methodology: Data references were identified through indexed journals and non-indexed sources. In this work, 13 000 articles were reviewed and 860 were selected based on their relevance. Results: Differences in prevalence were explained by local and regional variances in transmission routes or different public health measures. The lowest HCV prevalence ( 0.5%) estimates were from northern European countries and the highest (Z3%) were from Romania and rural areas in Greece, Italy and Russia. The main risk for HCV transmission in countries with wellestablished HCV screening programmes and lower HCV prevalence was injection drug use, which was associated with younger age at the time of infection and a higher infection rate among males. In other regions, contaminated glass syringes and Keywords diagnosis -epidemiology -HCV -hepatitis C -incidence -mortality -prevalence Conclusion: Despite the eradication of transmission by blood products, HCV infection continues to be one of the leading blood-borne infections in the region.Chronic hepatitis C (CHC) is a major health burden in Europe. Recent data suggest that patients with CHC have a higher overall morbidity and mortality (1, 2). A significant portion of liver transplantation in Europe is attributable to cirrhosis and hepatocellular carcinoma because of CHC (3). The socioeconomic impact of hepatitis C virus (HCV) infection is tremendous. The incidence of complications of CHC will not decline over the next 10 years despite improved efficacy of antiviral therapy because most patients with CHC remain undiagnosed (4). Prevention of new infections, HCV screening and early treatment have the potential to reduce the overall morbidity and mortality. However, the cost-effectiveness of HCV screening may depend on the HCV prevalence (5). Decisions on public health issues such as HCV screening and prevention measures are dependent on reliable epidemiological data regarding HCV prevalence and transmission routes. The epidemiological status in Europe is continuously evolving and may vary significantly among the different regions throughout Europe (6). Thus, different countries may need different strategies to reduce the overall burden of HCV infection.Because epidemiological data are the basis for the development of preventive measures, we aimed to systematically identify, review and characterize HCV epidemiology throughout Europe. We included Canada and Israel in our analysis because their healthcare systems and the epidemiological situation are similar to many European countries. MethodsA comprehensive review of the literature was used to gather country-specific data on risk factors, prevalence, number of diagnosed...

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Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel

Cornberg

Razavi

Alberti

et al. 2011

Liver International

369

294

View full text Add to dashboard Cite

show abstract

“…Viremic prevalence in 1995 was estimated at 1.1% (0.9–1.5%), equivalent to 115 000 (89 000–148 000) cases. The genotype distribution of the prevalent population was based upon the average from two studies reporting data from Portugal, weighted by sample size . The distribution of G1 subtypes was based upon data from a separate study .…”

Section: Resultsmentioning

confidence: 99%

Historical epidemiology of hepatitis C virus (HCV) in selected countries

Bruggmann

Berg

Øvrehus

et al. 2014

Journal of Viral Hepatitis

237

192

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SUMMARY. Chronic infection with hepatitis C virus (HCV) is a leading indicator for liver disease. New treatment options are becoming available, and there is a need to characterize the epidemiology and disease burden of HCV. Data for prevalence, viremia, genotype, diagnosis and treatment were obtained through literature searches and expert consensus for 16 countries. For some countries, data from centralized registries were used to estimate diagnosis and treatment rates. Data for the number of liver transplants and the proportion attributable to HCV were obtained from centralized databases. Viremic prevalence estimates varied widely between countries, ranging from 0.3% in Austria, England and Germany to 8.5% in Egypt. The largest viremic populations were in Egypt, with 6 358 000 cases in 2008 and Brazil with 2 106 000 cases in 2007. The age distribution of cases differed between countries. In most countries, prevalence rates were higher among males, reflecting higher rates of injection drug use. Diagnosis, treatment and transplant levels also differed considerably between countries. Reliable estimates characterizing HCV-infected populations are critical for addressing HCV-related morbidity and mortality. There is a need to quantify the burden of chronic HCV infection at the national level.

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“…This was based on a study of drug‐related mortality in eight European countries, including Portugal , and was adjusted to account for gender differences . It was estimated that 15.2% of the HCV population were infected through transfusion .…”

Section: Methodsmentioning

confidence: 99%

The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm

Sibley¹,

Han²,

Abourached³

et al. 2014

Journal of Viral Hepatitis

404

327

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SUMMARY. The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing.

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P.484 Epidemiological characterization of chronic hepatitis C in Portugal

Cited by 4 publications

References 0 publications

A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel

A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel

Historical epidemiology of hepatitis C virus (HCV) in selected countries

The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm

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