P(4-VP) based nanoparticles and composites with dual action as antimicrobial materials

Özay, Özgür; Akçalı, Alper; Otkun, Metin; Silan, Coşkun; Aktaş, Nahit; Şahiner, Nurettin

doi:10.1016/j.colsurfb.2010.05.013

Cited by 65 publications

(30 citation statements)

References 23 publications

(24 reference statements)

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“…The bands at about 3025 cm −1 (aromatic) for CH vibration, 2954-2923 cm −1 for aliphatic CH, 1723 cm −1 for C O, 1594 cm −1 for C C, 1407 cm −1 for C N, and 1216 cm −1 for C O C stretching frequencies were observed from crosslinker and monomer in accordance with the literature for the monomers and crosslinker used in cryogel preparation [24][25][26][27][28][29][30][31][32]. Moreover, the specific band for SPM monomer and the peaks for the crosslinker used were determined at 2979 cm −1 for aliphatic CH, 1716 cm 1458 cm −1 for CN in the VI ring, 1178 cm −1 vibration for SO 2 asymmetric stretching, and 1036-1009 cm −1 for S O stretching frequencies [25][26][27][28][29] were observed. The schematic representation of Co and Ni metal nanoparticle formation in p(SPM) cryogel matrices and their digital camera images are illustrated in Fig.…”

Section: Resultssupporting

confidence: 88%

Macroporous cryogel metal nanoparticle composites for H2 generation from NaBH4 hydrolysis in seawater

Şahiner

Yıldız

Şahiner

et al. 2015

Applied Surface Science

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Section: Resultssupporting

confidence: 88%

Macroporous cryogel metal nanoparticle composites for H2 generation from NaBH4 hydrolysis in seawater

Şahiner

Yıldız

Şahiner

et al. 2015

Applied Surface Science

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“…The results of % 5-FU loading and encapsulation efficiency were calculated, respectively using Eqs. (3) and (4). these data of %EE is presented in Table 1.…”

Section: Methodsmentioning

confidence: 94%

“…These bulk (macro) and nano-sized hydrogels, which are known to be smart materials with tunable properties, morphology, size, and hydrophilic/hydrophobic balance, are indispensable materials for numerous applications in biomedical fields such as drug delivery, catalysis, and the development of antimicrobial materials. [4][5][6][7] Due to their hydrophilic surface has a low interfacial free energy in contact with body fluids, which results in a low tendency for protein and cells to adhere to these surfaces. Moreover, the soft and rubbery nature of hydrogels minimizes irritation to surrounding tissues.…”

Section: Introductionmentioning

confidence: 99%

Dual Responsive Pectin Hydrogels and Their Silver Nanocomposites: Swelling Studies, Controlled Drug Delivery and Antimicrobial Applications

Reddy¹,

Eswaramma²,

Rao³

et al. 2014

Bulletin of the Korean Chemical Society

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Novel dual responsive pectin hydrogels composed from poly(acrylamidoglycolic acid-co-vinylcaprolactam)/ Pectin (PAV-PC) and also PAV-PC hydrogels are used as templates for the production of silver nanoparticles. 5-Fluorouracil is an anticancer drug and has been loaded in situ into PAV-PC hydrogels. Structure and morphology characterization of PAV-PC hydrogels were investigated by fourier transform infrared spectroscopy, differential scanning calorimetry, thermo gravimetric analysis, X-ray diffraction studies, scanning electron microscopy and transmission electron microscopy. The results revealed a molecular level dispersion of the drug in PAV-PC hydrogels. In vitro release of 5-fluorouracil from the PAV-PC hydrogels has been carried out in GIT fluids as well as in various temperatures. 5-Fluorouracil released from PAV-PC hydrogels was 50% at pH 1.2, and 85% at pH 7.4 within 24 h. The release profile was characterized with PAV-PC hydrogels and initial burst effect was significantly reduced in two buffer media (1.2 and 7.4), followed by a continuous and controlled release phase, the drug release mechanism from polymer was due to Fickian diffusion. In situ fabrication of silver nanoparticles inside the hydrogel network via the reduction of sodium borohydrate by PAV-PC chains led to hydrogel nanocomposites. The diameter of the nanocomposites was about 50-100 nm, suitable for uptake within the gastrointestinal tract due to their nanosize range and mucoadhesive properties. These nanocomposite PAV-PC hydrogels showed strong antimicrobial activity towards Bacillus subtilis (G+ve) and Escherichia coli (G-ve).

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“…The degradation of aqueous MO solution by PEI-Cu(II) hydrogel system is a rapid process, and can almost be completed in about 60 min. The PEI- Cu(II) hydrogel complex can play two roles simultaneously: adsorption and catalysis as MO is negatively charges and PEI hydrogels are positively charged due to the quaternized amine groups (Victoria et al 2014;Ozay et al 2010) during the degradation process. Kinetic studies suggest that the degradation process of MO can be described by the pseudo-first-order kinetic model.…”

Section: Resultsmentioning

confidence: 99%

Metil Oranj Bozunması ve Epinefrin Oksidasyonu için PEI-M [M:Cu(II) ve Co(II)] Hidrojel Katalizör

Şahiner¹,

Demirci²,

Ghorbanloo³

2015

Çanakkale Onsekiz Mart Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Here, we report the catalytic activity of catalyst derived from polyethylene imine-M (II) (PEI-M: Cu(II), and Co(II)) hydrogel composite in the presence of H 2 O 2 as an oxidant. The PEI-Cu(II)/H 2 O 2 heterogeneous composite was used in the degradation of an azo-dye, methyl orange (MO) in aqueous solution. In the presence of 63 mM H 2 O 2 , 100% of MO was removed in 80 min. The kinetics investigation of the processes demonstrated a pseudofirst-order kinetic model was applicable. Additionally, a pharmaceutical product, epinephrine (EP) was partially oxidized to adrenochrome by PEICo(II)/H 2 O 2 hydrogel composite system. About 50% of conversion to adrenochrome was reached in less than 55 min again comply with the pseudo-first-order Keywords: Hydrogel-metal ion composite; azo compound degradation; epinephrine oxidation; drug oxidation; hydrogel catalyst. Metil Oranj Bozunması ve Epinefrin Oksidasyonu için PEI-M [M:Cu(II) ve Co(II)] Hidrojel Katalizör ÖzetBu çalışmada, Polietilenimin-M(II) (PEI-M: Cu(II) ve Co(II)) hidrojel kompozitlerinin H2O2 indirgeyici olarak kullanılıdığı reaksiyonlarda katalitik aktiviteleri incelendi. Buna göre, PEI-Cu/H2O2 heterojen kompozitleri metil oranjın sulu çözeltisinde (MO) bozunma reaksiyonunda katalizör olarak kullanıldı. Metil oranj, 63 mM H2O2 varlı-ğında %100 olarak 80 dakikada ortamdan uzaklaştırıldı. Metil oranj bozunma reaksiyonunun kinetik çalışmalarında pseudo birinci dereceden kinetik modele uygulanabilir olduğu gösterildi. Bunlara ek olarak, bir ilaç olan epinefrin (adrenalin), PEI-Co(II)/H2O2 hidrojel kompozit sistemi varlığında adrenokrom'a yükseltgendi. Epinefrin'in yaklaşık %50'si 55 dakikadan daha az bir sürede adrenokroma dö-nüştürüldü ve pseudo birinci dereceden kinetik modele uygulanabilir olduğu gösterildi. MO ve EP yükseltgenmesi reaksiyonlarının aktivasyon enerjileri sırasıyla 44,09 ve 58,02 Anahtar Sözcükler: Hidrojel-metal iyon kompozit, azo bileşiklerinin bozunması, epinefrin yükseltgenmesi, ilaç yük-seltgenmesi, hidrojel kompozit.

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P(4-VP) based nanoparticles and composites with dual action as antimicrobial materials

Cited by 65 publications

References 23 publications

Macroporous cryogel metal nanoparticle composites for H2 generation from NaBH4 hydrolysis in seawater

Macroporous cryogel metal nanoparticle composites for H2 generation from NaBH4 hydrolysis in seawater

Dual Responsive Pectin Hydrogels and Their Silver Nanocomposites: Swelling Studies, Controlled Drug Delivery and Antimicrobial Applications

Metil Oranj Bozunması ve Epinefrin Oksidasyonu için PEI-M [M:Cu(II) ve Co(II)] Hidrojel Katalizör

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