P-4 Albumin Levels Have Strongassociation With Mortality in Covid-19 Infected Patiens

Abstract

Introduction To optimize hospital management of COVID-19 patients it is important to have parameters that allow us to identify patient with an increased risk of death. Although hypoalbuminemia has been related with severity in COVID-19, there is no agreement of the albumin cutoff points with a potential clinical use. Additionally, a measure of strength of the association between albumin levels and mortality has not been reported. Therefore, the aim of this study is to evaluate if Child Pug albumin categories are associated with mortality and obtain the strength of the association. Methods Patients admitted to hospitalization with a positive SARS CoV 2 PCR from 4 April to 24 June 2020 were analyzed. Three groups were formed based on Child-Pugh albumin categories. Death frequency were compared between groups and statistical significance of the difference were assessed using a Xi 2 test, strength of association between albumin levels and death was evaluated with a Kendall´s Tau B test. Results A total of 348 patients were studied, age was 54.4 ± 14.7 years, 250 (71.8%) were male and 182 patients died (52%). Association of Albumin level and Death is presented Table 1, Kendall Tau B shows that knowing albumin level improves in 32% the prediction of death and since it has a negative coefficient at a lower level of albumin, risk of death increase. Conclusions Kendall´s Tau-B shows a strong association between Child-Pug albumin categories and death, so is possible it´s use in clinical decisions as a marker of severity.

Association of Non-Alcoholic Fatty Liver Disease and Metabolic-Associated Fatty Liver Disease with COVID-19-Related Intensive Care Unit Outcomes: A Systematic Review and Meta-Analysis

“…Of the total 5286 patients, 1623 had severe COVID-19, with 33.17% (901/2716) of MAFLD patients having severe COVID-19 disease, as opposed to 28.09% (722/2570) of the non-MAFLD patients. The odds ratio was 1.59 for disease patients with and without MAFLD sensitivity analysis after excluding Tignanelli et al [28][29][30]34,36,38,40,43,[45][46][47][48]52].…”

“… Forest plot and meta-analysis of the need for invasive mechanical ventilation in COVI-19 patients with and without MAFLD sensitivity analysis after excluding Tignanelli et al [ 28 , 29 , 30 , 34 , 36 , 38 , 40 , 43 , 45 , 46 , 47 , 48 , 52 ]. …”

“…Figure 7. Forest plot and meta-analysis of the need for invasive mechanical ventilation in COVI-19 patients with and without MAFLD sensitivity analysis after excluding Tignanelli et al[28][29][30]34,36,38,40,43,[45][46][47][48]52].…”