P-38 Using a machine learning approach to study host-microbiome interactions in early-onset colorectal adenocarcinoma

Jayakrishnan, Thejus; Sangwan, Naseer; Barot, Shimoli V.; Farha, Nicole; Ahmad, Mariam; Xiang, Sheng; Aucejo, Federico; Conces, M.; Nair, Kanika G.; Krishnamurthi, Smitha; Schmit, Stephanie L.; Líška, Dávid; Rotroff, Daniel M.; Khorana, Alok A.; Kamath, Suneel D.

doi:10.1016/j.annonc.2023.04.094

Cited by 1 publication

(3 citation statements)

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“…It appears that certain bacterial genera such as Akkermansia and Bacteriodes are differentially abundant in young individuals who develop CRC as opposed to several other genera ( Bacillus , Staphylococcus , Listeria , Enterococcus , Pseudomonas , Fusobacterium , and Escherichia/Shigella) that are more abundant in CRC arising at the usual age [ 72 ]. Approaches such as plasma metabolomics analysis and machine learning are being used to further define the relationship between the altered microbiome in young individuals and CRC to identify microbiome-derived signatures for screening and therapy [ 73 , 74 ].…”

Section: Abnormal Gut Microbiome In Patients With Colorectal Cancermentioning

confidence: 99%

“…Further results are summarized in Table 1 . Surprisingly, these results go beyond chemotherapy and immunotherapy, with one study showing that germ-free mice undergoing total body irradiation combined with FMT before bone marrow transplantation displayed improved survival compared with ones not receiving FMT, suggesting the role of microbiome in preventing radiation-induced toxicity [ 74 ].…”

Section: Fecal Microbiota Transplantation In Colorectal Cancermentioning

confidence: 99%

“…The overall impact of gut microbiome alterations on colorectal cancer is summarized in Figure 3. marrow transplantation displayed improved survival compared with ones not receiving FMT, suggesting the role of microbiome in preventing radiation-induced toxicity [74].…”

Section: Rosshart Et Al 2017 [121]mentioning

confidence: 99%

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Gut Microbiome–Colorectal Cancer Relationship

Yadav,

Sainatham,

Filippov

et al. 2024

Microorganisms

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Traditionally, the role of gut dysbiosis was thought to be limited to pathologies like Clostridioides difficile infection, but studies have shown its role in other intestinal and extraintestinal pathologies. Similarly, recent studies have surfaced showing the strong potential role of the gut microbiome in colorectal cancer, which was traditionally attributed mainly to sporadic or germline mutations. Given that it is the third most common cancer and the second most common cause of cancer-related mortality, 78 grants totaling more than USD 28 million have been granted to improve colon cancer management since 2019. Concerted efforts by several of these studies have identified specific bacterial consortia inducing a proinflammatory environment and promoting genotoxin production, causing the induction or progression of colorectal cancer. In addition, changes in the gut microbiome have also been shown to alter the response to cancer chemotherapy and immunotherapy, thus changing cancer prognosis. Certain bacteria have been identified as biomarkers to predict the efficacy of antineoplastic medications. Given these discoveries, efforts have been made to alter the gut microbiome to promote a favorable diversity to improve cancer progression and the response to therapy. In this review, we expand on the gut microbiome, its association with colorectal cancer, and antineoplastic medications. We also discuss the evolving paradigm of fecal microbiota transplantation in the context of colorectal cancer management.

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Section: Abnormal Gut Microbiome In Patients With Colorectal Cancermentioning

confidence: 99%

Section: Fecal Microbiota Transplantation In Colorectal Cancermentioning

confidence: 99%