P.321 Incidence de l’adénocarcinome du pancréas dans le département du Finistère entre 1990 et 2004 et survie des malades

Coadou, G. Le; Bessaguet, C.; Faycal, J.; Cauvin, J.-M.; Robaszkiewicz, M.; Gouérou, H; Nousbaum, J.-B.

doi:10.1016/s0399-8320(09)73012-x

Cited by 2 publications

(1 citation statement)

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“…Second, previous studies reported an incidence rate of 22.7 cases of VTE per 1000 patients with pancreatic cancer [6]. And third, in our district of 342 000 inhabitants [17], the incidence of pancreatic cancer was estimated in 2004 at 5.41/100 000 inhabitants/year in men and 3.56/ 100 000 inhabitants/year in women [18].…”

Section: Discussionmentioning

confidence: 72%

Venous thromboembolism in patients with pancreatic cancer: implications of circulating tissue factor

Delluc

Rousseau

Delluc

et al. 2011

Blood Coagulation &Amp; Fibrinolysis

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Among cancers, pancreatic cancer is known to be associated with a higher incidence of venous thromboembolism (VTE). The aim of the study was to determine the implication of circulating tissue factor (TF) in VTE related to active pancreatic cancer. One hundred and sixty-four consecutive patients who participated to the Etude des Determinants et Interactions de la Thrombose veineuse (EDITH) study between January 2005 and August 2007 for symptomatic VTE related to active pancreatic cancer (n = 8), active cancer of other location (n = 42) or classified as unprovoked (n = 114) were included. TF activity (TFa) was measured in a one-stage kinetic chromogenic method. There were no differences of median TFa levels between patients with VTE related to cancer of other type than pancreas [2.01 pmol/l range (0.05-43.92)] and patients with unprovoked VTE [1.78 pmol/l (range 0.05-63.72), P = 0.21]. Median TFa levels were higher in patients with VTE related to pancreatic cancer [12.67 pmol/l (range 0.05-112.04)] than in patients with VTE related to cancer of other type [2.01 pmol/l (range 0.05-43.92), P = 0.02]. Higher levels of circulating TFa during the course of pancreatic cancer may explain the higher incidence of VTE associated with this type of cancer.

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Section: Discussionmentioning

confidence: 72%