P.3.c.038 Adjunctive mood stabilising treatment: the effects on hostility and impulsivity among patients with schizophrenia

Suzana, S; Olivera, Žikić; Gordana, N.G. Nikolic; Violeta, S.V. Slavkovic; Dragoslava, G.D. Gugleta; Vladica, Simona

doi:10.1016/s0924-977x(09)70845-4

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Does evidence exist that any adjunctive medication will reduce overt aggression or hostility in persons with schizophrenia spectrum disorders? [70][71][72]88,[132][133][134][135][136][137][138][139][140][141][142] (Table 4) Fifteen articles were identified that reported relevant data. One paper 137 was also reported in Table 5 because the subjects were preselected for aggressiveness.…”

Section: Resultsmentioning

confidence: 99%

Pharmacological Management of Persistent Hostility and Aggression in Persons With Schizophrenia Spectrum Disorders: A Systematic Review

Victoroff

Coburn

Reeve

et al. 2014

JNP

View full text Add to dashboard Cite

The incidence of aggressive behaviors is higher among persons with schizophrenia spectrum disorders (SSDs) than among persons without such disorders. This phenomenon represents a risk to the well-being of patients, their families, and society. The authors undertook a systematic review of the English language literature to determine the efficacy of neuropharmacological agents for the management of hostility and aggression among persons with SSDs. The search combined findings from the Medline, EMBASE, and PsycINFO databases. Ninety-two full text articles were identified that reported relevant findings. The American Academy of Neurology criteria were used to determine levels of evidence. Paliperidone-extended release is probably effective for the management of hostility among inpatients with SSDs who have not been preselected for aggression (Level B). Clozapine is possibly more effective than haloperidol for the management of overt aggression and possibly more effective than chlorpromazine for the management of hostility among inpatients with SSDs who have not been preselected for aggression (Level C). Clozapine is also possibly more effective than olanzapine or haloperidol for reducing aggression among selected physically assaultive inpatients (Level C). Adjunctive propranolol, valproic acid, and famotidine are possibly effective for reducing some aspects of hostility or aggression among inpatients with SSDs (Level C). Paliperidone-extended release currently appears to be the agent for the management of hostility among inpatients with SSDs for which there is the strongest evidence of efficacy.

show abstract

Section: Resultsmentioning

confidence: 99%

Pharmacological Management of Persistent Hostility and Aggression in Persons With Schizophrenia Spectrum Disorders: A Systematic Review

Victoroff

Coburn

Reeve

et al. 2014

JNP

View full text Add to dashboard Cite

show abstract

Valproate for schizophrenia

Wang

Xia

Helfer

et al. 2016

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

There is limited evidence, based on a number of trials, that the augmentation of antipsychotics with valproate may be effective for overall clinical response, and also for specific symptoms, especially in terms of excitement and aggression. However, this evidence was entirely based on open RCTs. Moreover, valproate was associated with a number of adverse events among which sedation and dizziness appeared significantly more frequently than in the control groups. Further randomised studies which are blinded are necessary before any clear recommendation can be made. Ideally these would focus on people with schizophrenia and aggression, on those with treatment-resistant forms of the illness and on those with schizoaffective disorders.

show abstract

Risperidone for psychosis-induced aggression or agitation (rapid tranquillisation)

Ostinelli

Hussein²,

Ahmed

et al. 2018

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

P.3.c.038 Adjunctive mood stabilising treatment: the effects on hostility and impulsivity among patients with schizophrenia

Cited by 3 publications

References 0 publications

Pharmacological Management of Persistent Hostility and Aggression in Persons With Schizophrenia Spectrum Disorders: A Systematic Review

Pharmacological Management of Persistent Hostility and Aggression in Persons With Schizophrenia Spectrum Disorders: A Systematic Review

Valproate for schizophrenia

Risperidone for psychosis-induced aggression or agitation (rapid tranquillisation)

Contact Info

Product

Resources

About