2013
DOI: 10.1097/01.mib.0000439019.90649.75
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P-221 Atg16l1 Deficiency Leads to Defects in Autophagy in Dendritic Cells and Macrophages

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“…10,11 Previous studies revealed that alterations in the autophagic machinery, such as in ATG16L1, may result in the ineffective elimination of pathogens and the persistent activation of the inflammatory cascade in the intestine, which may contribute to the pathogenesis of IBD. 12 Although the roles of ATG16L1 in intestinal epithelial cells and macrophages for bacteria interactions have been demonstrated extensively, 13,14 the definite mechanism has yet to be investigated, particularly in DCs. In our previous study, we preliminary demonstrated the protection role of Atg16l1 in CD11c + DCs in murine colitis.…”
Section: Introductionmentioning
confidence: 99%
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“…10,11 Previous studies revealed that alterations in the autophagic machinery, such as in ATG16L1, may result in the ineffective elimination of pathogens and the persistent activation of the inflammatory cascade in the intestine, which may contribute to the pathogenesis of IBD. 12 Although the roles of ATG16L1 in intestinal epithelial cells and macrophages for bacteria interactions have been demonstrated extensively, 13,14 the definite mechanism has yet to be investigated, particularly in DCs. In our previous study, we preliminary demonstrated the protection role of Atg16l1 in CD11c + DCs in murine colitis.…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, genome‐wide association studies have now identified autophagy‐related 16‐like 1 (ATG16L1) to be associated with IBD 10,11 . Previous studies revealed that alterations in the autophagic machinery, such as in ATG16L1, may result in the ineffective elimination of pathogens and the persistent activation of the inflammatory cascade in the intestine, which may contribute to the pathogenesis of IBD 12 . Although the roles of ATG16L1 in intestinal epithelial cells and macrophages for bacteria interactions have been demonstrated extensively, 13,14 the definite mechanism has yet to be investigated, particularly in DCs.…”
Section: Introductionmentioning
confidence: 99%