P-161 Evaluation of GLP-2 Levels in Crohnʼs Disease

Coy, Cláudio Saddy Rodrigues; Calixto, Antônio Ramos; Vasques, Ana Carolina Junqueira; Rossi, Debora Helena; Geloneze, Bruno; Pareja, José Carlos; Daniela, Magro

doi:10.1097/01.mib.0000480279.44871.c5

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Modulation Of Iscs By Gut Microbiota Via the Epithelial Route1

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2021

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“…Significantly reduced levels of circulating and tissue-associated GLP-2 have been reported in IBD, while epithelial wound healing during restitution has been linked with improved GLP-2 levels. 96 , 97 Given the evidence for regulation of GLP-2 expression via microbial cues, it might be postulated that the effects of the characteristic depletion of SCFAs in IBD may be mediated through reduced release of GLP2 98 ( figure 4f ).…”

Section: Modulation Of Iscs By Gut Microbiota Via the Epithelial Routementioning

confidence: 99%