P‐12 
Comparative study of griseofulvin and terbinafine therapy in the treatment of canine and feline dermatophytosis

Abstract

Skin physiology in cats has received little attention. The aim of this study was to evaluate the long-term influence of sex, time and the level of dietary fat and energy on the dynamics and qualities of the hair coat. Twenty-four European short-haired laboratory cats were followed over a 1-year period. They were divided into eight groups of three, according to: sex (12 males and 12 females), sexual status (intact or neutered) and diets [(high energy 4300 kcal/kg as fed, 21% fat) vs. (moderate energy 3500 kcal/kg as fed, 10% fat)]. Both diets were fed for 6 months to all cats following a cross-over design. The following parameters were evaluated throughout the study: thickness of hair coat and hair lengths (neck, rump, lateral, flank), hair regrowth (after periodic clippings of 25 cm 2 areas), and telogen/anagen ratio. The thickness of the hair coat initially varied from 1.2-1.7 cm on the neck, 1-1.4 cm on the rump, 1.8-2.5 cm on the flank, and hair shaft lengths were 1.7-2.5, 3.7-3.9 and 2.5-3.2 cm, respectively. Comparison of values revealed few statistical differences: increase of the thickness of hair coat in neutered cats (male and female) during the study, and increase of the length of lateral hairs in all groups during the study. Over all periods and in all groups, the curve of growth was similar (rapid then slower). Some transient variations were attributed to temporary changes in ambient conditions. In conclusion, neither sex, nutrition or season (in housed cats) influenced the general quality of hair coat, in particular hair regrowth. Funding: Royal Canin. P-2Evaluation of the influence of sex, diet and time on skin pH and surface lipids of cats P. BOURDEAU, K. W. TAYLOR, P. NGUYEN and V. BIOURGE National Veterinary School of Nantes, Nantes, France; Royal Canin, Aimargues, France Skin lipids and pH are two factors classically considered of importance in homeostatic characteristics of skin. Skin physiology in cats has received little attention. The aim of this study was to evaluate the long-term influence of sex, sexual status, season, and dietary fat and energy on these parameters. Twenty-four European short-haired laboratory cats, 14 months of age, were followed over a 1-year period. They were divided into 8 groups of three, according to: sex (12 males and 12 females), sexual status (intact or neutered) and diets [(high energy 4300 kcal/kg as fed, 21% fat) vs. (moderate energy 3500 kcal/kg as fed, 10% fat)]. Both diets were fed to all cats for 6 months following a cross-over design. Parameters regularly evaluated were skin pH and hair total lipid content (extraction from samples of 0.6-1.2 g of clipped hairs). The pH of the skin varied from 6.6-6.8 initially to 7.2-7.4 at the end of the study. This increase was significant only in intact animals (male and female). The dietary changes did not affect skin pH. Hair total lipid content was not affected by sex or the diets but slightly increased in all groups over the study period from 1.5-2.4 to 2.4-3.3%. In conclusion, skin pH appeared to be potentially m...

Successful Treatment of Canine Sporotrichosis with Terbinafine: Case Reports and Literature Review

“…The occurrence of gastrointestinal adverse effects (GAE) such as anorexia, vomiting, or diarrhea, as well as the increase of hepatic enzymes, was described in canine sporotrichosis cases treated with azolic antifungal agents [6]. In dogs with dermatophytosis and malasseziasis treated with terbinafine (20-30 mg/ kg/day), the occurrence of GAE was low [57,58], and the increase of alanine aminotransferase was transient, with parameters back to normal 1 week after discharge [58].…”

Diagnosis and treatment of dermatophytosis in dogs and cats.

“…Fifty seven studies involving either spontaneous ( n = 42) or experimental ( n = 15) M. canis infections in cats and dogs ( n = 2,027) were identified and of these, 30 described Wood's lamp findings . When data were pooled from studies describing the first examination of animals with spontaneous disease, 72% (378 of 523) of animals were Wood's lamp positive .…”

“…Given that this drug is not licensed for use in small animals, there are no published target animal safety studies for review. Published reports of its use either as treatment for dermatophytosis or pharmacokinetic studies were reviewed for mention of adverse effects . Because of the low number of dogs treated with terbinafine described in the literature, two studies involving the use of terbinafine for the treatment of Malassezia were included .…”

“…There are 10 studies describing the use of terbinafine to treat small animal dermatophytosis . The studies are summarized in Table and span a time frame from 1998 to 2014, during which a wide range of doses from 5 mg/kg to 40 mg/kg were used once daily.…”

“…Fifteen prospective studies described the treatment of 242 cats and dogs treated with griseofulvin (Table ) . In four studies, concurrent topical therapy was used on all or part of the study group animals and in one study cats were pre‐treated with lufenuron .…”