P.1.062 Naturalistic study of outcome of mood stabilizing treatment in bipolar disorder

Garnham, Julie; Munro, A.; Teehan, Andrew; Slaney, Claire; Duffy, Anne; MacDougall, Marsha; Passmore, Michael J.; Alda, Martin

doi:10.1016/s0924-977x(03)91773-1

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Clinical Traits Associated With Treatment Outcome1

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2013

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Cited by 3 publications

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“…In a recent study we evaluated over 120 subjects treated in a naturalistic setting. Of 69 patients treated with valproate, nine met the criteria of full response but could not be differentiated from nonresponders based on clinical profiles [Garnham et al, 2002].…”

Section: Clinical Traits Associated With Treatment Outcomementioning

confidence: 99%

Loss of heterozygosities in Barrett esophagus, dysplasia, and adenocarcinoma detected by esophageal brushing cytology and gastroesophageal biopsy

Lin

Finkelstein²,

Zhu

et al. 2009

Cancer Cytopathology

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Section: Clinical Traits Associated With Treatment Outcomementioning

confidence: 99%

Loss of heterozygosities in Barrett esophagus, dysplasia, and adenocarcinoma detected by esophageal brushing cytology and gastroesophageal biopsy

Lin

Finkelstein²,

Zhu

et al. 2009

Cancer Cytopathology

View full text Add to dashboard Cite

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S3-Leitlinien zu bipolaren Störungen sind zeitgerechte und wichtige Instrumente für die klinische Praxis. Kontra

Grof

Müller‐Oerlinghausen

2013

Nervenarzt

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A critical appraisal of lithium’s efficacy and effectiveness: the last 60 years

Grof

Müller‐Oerlinghausen

2009

Bipolar Disorders

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The history that depicts the evaluation of lithium's efficacy presents an interesting contrast: on the one hand, conviction that, of all psychotropic drugs, lithium has the best demonstrated efficacy; on the other hand, repeated attempts to question it. Those contesting lithium's stabilizing abilities have argued from several angles, for example that the proof was methodologically incorrect or insufficient, that the number of responders is small, or that the response is poor in practice and does not last. But there is a good explanation for this paradox. While the early challenges to lithium's value in recurrent mood disorders reflected mainly that psychiatry had not yet developed a methodology suitable for testing long-term efficacy, more recent questioning has resulted mostly from retesting its efficacy and effectiveness in a substantially broadened bipolar spectrum, outside the classical diagnosis. Lithium, however, continues to stabilize very well the patients suffering from typical bipolar disorder--the condition for which its efficacy was originally demonstrated. More recently, lithium has also proven to dramatically reduce suicidal behavior and mortality and to augment markedly the efficacy of antidepressants in unresponsive patients.

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P.1.062 Naturalistic study of outcome of mood stabilizing treatment in bipolar disorder

Cited by 3 publications

References 0 publications

Loss of heterozygosities in Barrett esophagus, dysplasia, and adenocarcinoma detected by esophageal brushing cytology and gastroesophageal biopsy

Loss of heterozygosities in Barrett esophagus, dysplasia, and adenocarcinoma detected by esophageal brushing cytology and gastroesophageal biopsy

S3-Leitlinien zu bipolaren Störungen sind zeitgerechte und wichtige Instrumente für die klinische Praxis. Kontra

A critical appraisal of lithium’s efficacy and effectiveness: the last 60 years

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