P-099. Hepatitis C virus infection and assisted reproduction

Passos, E.P.; Silveira, Themis Reverbel da; Facin, Andrea Cintra; Cunha, Filho J.S.L.; Guerin, Yherar Lavic Serrano; Silva, I.C.

doi:10.1093/humrep/14.suppl_3.190

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“…Although HCV viral RNA has been detected in the semen, the role of sexual, perinatal, and other possible nonparenteral routes of HCV transmission is still unclear (7)(8)(9), but from the available evidence this risk appears to be minimal (10). Indeed, even in the presence of acute infection, semen viremia is extremely low as evaluated by PCR (11)(12)(13)(14), suggesting a low risk of sexual transmission. Thus IVF is not contraindicated in these couples (15,16).…”

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confidence: 99%

Reproductive Performance of Couples Discordant for Hepatitis B and C Following IVF Treatment

Pirwany

Phillips

Kelly

et al. 2004

J Assist Reprod Genet

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Purpose : To examine the reproductive performance of hepatitis B (HBV) and C (HCV) discordant couples following IVF-ET. Methods : A retrospective cohort study of 25 IVF-ET cycles in HBV and HCV discordant couples was performed. Thirteen patients in the study cohort were discordant for HBV (10 males and 3 females), and 12 (9 males and 3 females) for HCV. Twenty-seven consecutive age matched patients comprised the control group. All patients underwent controlled ovarian hyperstimulation using the long downregulation protocol followed by IVF or ICSI. Results : Patients in the three groups (HBV, HCV, and controls) had similar ages, and day 3 FSH concentrations. Despite comparable response to COH, and similar fertilization, and cleavage rates in the three groups, couples discordant for HBV or HCV had significantly poorer implantation and pregnancy rates (7.7%, 0% respectively) compared with controls (41%). Conclusions : Despite comparable response to COH, HBV and HCV positive discordant couples, have significantly lower implantation and pregnancy rates compared with age-matched controls.

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