P.0885 The effect of psilocybin therapy for depression on low-frequency brain activity in response to music

Neuroimaging Correlates of Treatment Response with Psychedelics in Major Depressive Disorder: A Systematic Review

“…Of the 42 articles, 16 were excluded due to focusing on psychedelic interventions in healthy individuals, 14 due to being unrelated to psychedelic interventions or depression, 5 due to being non-primary articles (i.e., book chapters, reviews), and 1 due to having no accessible results. After assessing the full text of the 6 remaining articles for eligibility, 5 published studies 56 – 60 and 1 conference abstract 61 , 62 were included. An additional article by Daws et al 63 (2022) was retrieved from other sources (i.e., PubMed).…”

“…An additional article by Daws et al 63 (2022) was retrieved from other sources (i.e., PubMed). The conference abstract included in this review by Wall et al 61 , 62 (2021) has also been recently made available as a pre-print. 62 Detailed results of the published studies are provided in Table 1 .…”

“… 62 Detailed results of the published studies are provided in Table 1 . It is important to note that 4 out of 7 published studies 56 – 58 , 61 , 62 included in this review reported their neuroimaging and clinical findings from the same cohort of subjects. Therefore, the main characteristics of the studies listed in Table 1 were similar to each other.…”

“…Five published studies 56 – 58 , 60 , 63 and one conference abstract 61 , 62 used psilocybin as their primary intervention. Of these studies, Daws et al 63 (2022) conducted both an open-label trial and a randomized controlled trial (RCT); these two trials will be referred to separately throughout the review.…”

“…Roseman et al 58 (2018) was categorized as a feasibility trial but did not include a placebo group. Lastly, the conference abstract 61 , 62 followed an interventional, open-label and single-group assignment design.…”