P-08 Borderline true hyperthermia (BTH) plus additional L-PAM bolus in the isolated perfusion for stage III lower limb melanoma. Our experience with 93 ILP
“…In our institution, over the years, progresses in technologies and methodology have improved the results with regard to side-effects through the carrying out of safer and more acceptable procedures in spite of the use of the borderline true hyperthermia. In addition, previous clinical results reported in our pilot study [ 34 ] demonstrated that borderline hyperthermia with an increase of L-PAM concentration in the advanced lower limb melanoma (stage III) has improved the locoregional disease-free interval and the overall survival rate.…”
Background: The aim of this retrospective study was to assess the results concerning the regional and systemic toxicity and complications in 242 chemo-hyperthermal treatments (HILPs) for lower limb melanoma.
“…In our institution, over the years, progresses in technologies and methodology have improved the results with regard to side-effects through the carrying out of safer and more acceptable procedures in spite of the use of the borderline true hyperthermia. In addition, previous clinical results reported in our pilot study [ 34 ] demonstrated that borderline hyperthermia with an increase of L-PAM concentration in the advanced lower limb melanoma (stage III) has improved the locoregional disease-free interval and the overall survival rate.…”
Background: The aim of this retrospective study was to assess the results concerning the regional and systemic toxicity and complications in 242 chemo-hyperthermal treatments (HILPs) for lower limb melanoma.
“…Between March 1990 and December 2008, 120 BTH‐ILPs for lower limb melanoma were performed with a standard dose of 10 mg/L limb volume of melphalan with or without D ‐actinomicin ( D ‐act) plus an additional bolus of 5 mg/L of L ‐PAM (2M‐BTH protocol). A preliminary pilot study we carried out verified that our BTH‐ILP procedure would be accompanied by unacceptable toxicity 10.…”
Our procedure is an important therapeutic option. The results suggest a marked local control of the recurrent disease. The LRFI is longer than for those treated with other treatment schedules.
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