P.0429 Differential expression of serum extracellular vesicle microRNAs and analysis of target-gene pathways in major depressive disorder

Haymour, N.; Kaiser, Sophie; Hartmann-Riemer, Matthias N.; Guetter, Karoline; Klaus, Früh; Cathomas, Flurin; Seifritz, Erich; Bergamini, Giorgio; Russo, Giorgio; Pryce, Christopher R.

doi:10.1016/j.euroneuro.2021.10.402

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“…These EVs can reflect the pathophysiological changes of the CNS to a certain extent, giving them potential as biomarkers of MDD. Some researchers compared EVs between depression patients or depression model animals and healthy controls and found many differentially expressed miRNAs ( 55 , 66 , 99 , 100 )and proteins ( Table 1 ). These differentially expressed proteins and miRNAs may be biomarkers of MDD and help us further explore the pathophysiological mechanism of MDD.…”

Section: Discussionmentioning

confidence: 99%

The roles of extracellular vesicles in major depressive disorder

et al. 2023

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Major depressive disorder (MDD) is a serious mental disease characterized by depressed mood, loss of interest and suicidal ideation. Its rising prevalence has rendered MDD one of the largest contributors to the global disease burden. However, its pathophysiological mechanism is still unclear, and reliable biomarkers are lacking. Extracellular vesicles (EVs) are widely considered important mediators of intercellular communication, playing an important role in many physiological and pathological processes. Most preclinical studies focus on the related proteins and microRNAs in EVs, which can regulate energy metabolism, neurogenesis, neuro-inflammation and other pathophysiological processes in the development of MDD. The purpose of this review is to describe the current research progress of EVs in MDD and highlight their potential roles as biomarkers, therapeutic indicators and drug delivery carriers for the treatment of MDD.

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