P.033 Attenuation of alcohol-cue modulated insula connectivity by naltrexone predicts relapse in alcohol-dependent patients: a longitudinal clinical neuroimaging trial

Bach, Patrick; Weil, Georg; Pompili, Enrico; Hoffmann, Sabine; Vollstädt‐Klein, Sabine; Koehler, Peter; Kiefer, Falk; Sommer, Wolfgang H.

doi:10.1016/j.euroneuro.2020.09.036

Cited by 2 publications

(2 citation statements)

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“…With regard to circuits, increased connectivity following alcohol-associated cue presentation is observed between the right posterior insular and the bilateral anterior cingulate cortex in alcohol-dependent patients compared to healthy controls (Bach et al, 2020). Importantly, the connectivity between these two brain regions is reduced in individuals treated with the opioid antagonist naltrexone-a potential biomarker for treatment response (Bach et al, 2020). Given the broader role of the insular in interoceptive processing, particularly in response to alcohol-associated cues, activity in this brain region is not surprising.…”

Section: The Role Of the Anterior Insular Cortex In Alcohol Use Disordermentioning

confidence: 99%

“…One study has also shown increased BOLD insular activity in alcohol-dependent women in response to alcohol-related cues (Tapert et al, 2004). With regard to circuits, increased connectivity following alcohol-associated cue presentation is observed between the right posterior insular and the bilateral anterior cingulate cortex in alcohol-dependent patients compared to healthy controls (Bach et al, 2020). Importantly, the connectivity between these two brain regions is reduced in individuals treated with the opioid antagonist naltrexone-a potential biomarker for treatment response (Bach et al, 2020).…”

Section: The Role Of the Anterior Insular Cortex In Alcohol Use Disordermentioning

confidence: 99%

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It’s more than just interoception: The insular cortex involvement in alcohol use disorder

Campbell

Lawrence

2021

Journal of Neurochemistry

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The insular cortex (insula or 'the island of Reil') is a complex brain structure that forms part of the cerebral cortex (Reil, 1809). It has distinct anterior-posterior and dorsal-ventral divisions and is known as a cortical integration hub, with connectivity to extensive cortical and subcortical brain regions (reviewed in (Gogolla, 2017)). Of note, the insular cortex has numerous connections with the amygdaloid complex and the thalamus (Reep et al., 1996). Strong intra-insular networks also exist (Reep et al., 1996). The widespread connectivity and spatial organization of the insular cortex contribute to the relative lack of understanding of this brain structure. Traditionally, the insular had a known role as a visceral-somatic structure, responsible for various sensory and motor responses (Penfield & Boldrey, 1937;Rasmussen & Penfield, 1947). However, the known functions of the insular cortex have expanded in recent years. The insular is activated by olfactory stimuli, cognitive tasks, perceptions and emotions (Kurth et al., 2010). One well-known function of the insular cortex is in interoception, activated by cues and internal drives to modulate motivated behaviour (Craig, 2009). The involvement of the insular cortex in motivated behaviour suggests that it integrates with key reward circuitry. Indeed, the insular has connections with the ventral striatum, particularly the nucleus accumbens core, and the ventral tegmental area/ substantia nigra (Allen et al., 1991;Ohara et al., 2003;Wright & Groenewegen, 1996). Importantly, dopamine, gamma-aminobutyric acid (GABA) and glutamate appear to be key neurotransmitters involved in the function of the insular cortex (Betka et al., 2019;Ohara et al., 2003). One class of disorders where motivated behaviours are augmented include substance use disorders. Corticostriatal circuits have long been associated with substance use disorders, however, these studies have traditionally focussed on prefrontal

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Section: The Role Of the Anterior Insular Cortex In Alcohol Use Disordermentioning

confidence: 99%

Section: The Role Of the Anterior Insular Cortex In Alcohol Use Disordermentioning

confidence: 99%

It’s more than just interoception: The insular cortex involvement in alcohol use disorder

Campbell

Lawrence

2021

Journal of Neurochemistry

View full text Add to dashboard Cite

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MRI texture-based radiomics analysis for the identification of altered functional networks in alcoholic patients and animal models

Ruiz-España

Ortiz-Ramón

Pérez-Ramírez

et al. 2023

Computerized Medical Imaging and Graphics

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P.033 Attenuation of alcohol-cue modulated insula connectivity by naltrexone predicts relapse in alcohol-dependent patients: a longitudinal clinical neuroimaging trial

Cited by 2 publications

References 4 publications

It’s more than just interoception: The insular cortex involvement in alcohol use disorder

It’s more than just interoception: The insular cortex involvement in alcohol use disorder

MRI texture-based radiomics analysis for the identification of altered functional networks in alcoholic patients and animal models

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